**-Postprandial pancreatic [¹¹C]methionine uptake after pancreaticoduodenectomy mirrors basal beta cell function and insulin release

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• 作者：Emanuel Steiner ; Lukas Kazianka…
• 关键词：[11C]Methionine ; Positron emission tomography ; Pancreas ; Gastric emptying ; Insulin ; Beta cell function
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：3
• 页码：509-516
• 全文大小：747KB
• 刊物类别：Medicine
• 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1619-7089
• 卷排序：44

文摘

Purpose[S-methyl-11C]-L-methionine ([11C]MET) uptake in the pancreas might be a central indicator of beta cell function. Since gastric emptying was recently shown to influence glycemic control in subjects after pancreaticoduodenectomy (PD, the surgical treatment of neoplasms of the pancreas head), we looked for imaginable relationships between gastric emptying, pre- and postprandial insulin concentrations, and [11C]MET uptake.