Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer

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• 作者：Jun Zhang ; Zhongqiu Lin ; Yali Gao…
• 关键词：Cervical cancer ; Diagnosis ; Long noncoding RNA ; MEG3 ; Methylation ; Prognosis
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：36
• 期：1
• 全文大小：1465KB
• 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
• 出版者：BioMed Central
• ISSN：1756-9966
• 卷排序：36

文摘

BackgroundOur previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG3 inactivation in cervical cancer, remain unclear. In this study, we aimed to further elucidate the role and potential inactivation mechanism of MEG3 in cervical cancer.