Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

详细信息    查看全文

• 作者：Dominik Geisel ; Lutz Lüdemann ; Vera Fr?ling ; Maciej Malinowski…
• 关键词：MRI ; Liver function ; Mebrofenin scintigraphy ; EOB ; Gadoxetic acid
• 刊名：European Radiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：25
• 期：5
• 页码：1384-1391
• 全文大小：1,435 KB
• 参考文献：1. Manizate, F, Hiotis, SP, Labow, D, Roayaie, S, Schwartz, M (2010) Liver functional reserve estimation: state of the art and relevance for local treatments: the Western perspective. J Hepatobiliary Pancreatol Sci 4: pp. 385-388 CrossRef
  2. Graaf, W, Lienden, KP, Gulik, TM, Bennink, RJ (2010) (99m)Tc-mebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy. J Nucl Med 2: pp. 229-236 CrossRef
  3. Saito, K, Ledsam, J, Sourbron, S (2012) Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. J Magn Reson Imaging 37: pp. 1109-1114 CrossRef
  4. Nilsson, H, Nordell, A, Vargas, R, Douglas, L, Jonas, E, Blomqvist, L (2009) Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI. J Magn Reson Imaging 6: pp. 1323-1331 CrossRef
  5. Graaf, W, Lienden, KP, Esschert, JW, Bennink, RJ, Gulik, TM (2011) Increase in future remnant liver function after preoperative portal vein embolization. Br J Surg 6: pp. 825-834 CrossRef
  6. Erdogan, D, Heijnen, BH, Bennink, RJ (2004) Preoperative assessment of liver function: a comparison of 99mTc-mebrofenin scintigraphy with indocyanine green clearance test. Liver Int 2: pp. 117-123 CrossRef
  7. Yamada, A, Hara, T, Li, F (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 3: pp. 727-733 CrossRef
  8. Geisel, D, Lüdemann, L, Keuchel, T (2013) Increase in left liver lobe function after preoperative right portal vein embolisation assessed with gadolinium-EOB-DTPA MRI. Eur Radiol 9: pp. 2555-2560 CrossRef
  9. Neuhaus, P, Thelen, A, Jonas, S (2012) Oncological superiority of hilar en bloc resection for the treatment of hilar cholangiocarcinoma. Ann Surg Oncol 5: pp. 1602-1608 CrossRef
  10. Klatskin, G (1965) Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis: an unusual tumor with distinctive clinical and pathological features. Am J Med 2: pp. 241-256 CrossRef
  11. Neuhaus, P, Jonas, S, Bechstein, WO (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 6: pp. 808-818 CrossRef
  12. Dinant, S, Gerhards, MF, Rauws, EAJ, Busch, ORC, Gouma, DJ, Gulik, TM (2006) Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor). Ann Surg Oncol 6: pp. 872-880 CrossRef
  13. Agrawal, S, Belghiti, J (2011) Oncologic resection for malignant tumors of the liver. Ann Surg 4: pp. 656 CrossRef
  14. Jonas, S, Benckert, C, Thelen, A, Lopez-H?nninen, E, R?sch, T, Neuhaus, P (2008) Radical surgery for hilar cholangiocarcinoma. Eur J Surg Oncol 3: pp. 263 CrossRef
  15. Ekman, M, Fj?lling, M, Holmberg, S, Person, H (1992) IODIDA clearance rate: a method for measuring hepatocyte uptake function. Transplant Proc 1: pp. 387-388
  16. Ekman, M, Fj?lling, M, Friman, S, Carlson, S, Volkmann, R (1996) Liver uptake function measured by IODIDA clearance rate in liver transplant patients and healthy volunteers. Nucl Med Commun 3: pp. 235-242 CrossRef
  1
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function. Methods Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24?h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T max, T 1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL. Results Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r 2--.802, p--.001) and RE for LLL (r 2--.704, p--.005) and moderate correlation with HUI for LLL (r 2--.560, p--.037) and RE for RLL (r 2--.620, p--.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r 2--.775, p--.002). Conclusions Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function. Key points -Information about liver function can be acquired with routine Gd-EOB-MRI. -Gd-EOB-MRI and 99m Tc-mebrofenin HBS show elevated function of non-embolized lobe. -Gd-EOB-MRI and 99m Tc-mebrofenin HBS can determine lobar liver function.