Optimized separation of left and right liver lobe in dynamic 99mTc-mebrofenin hepatobiliary scintigraphy using a hybrid SPECT-CT scanner
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- 作者：Dominik Geisel (1)
Lutz Lüdemann (3)
Bernhard Gebauer (1)
Vera Fr?ling (1)
Vikas Prasad (2)
Uwe Heimann (1) (2)
Martin Stockmann (4)
Maciej Malinowski (4)
Bernd Hamm (1)
Winfried Brenner (2)
Timm Denecke (1) (2) - 关键词：MRI ; SPECT ; CT ; Liver function ; Mebrofenin scintigraphy
- 刊名：Annals of Nuclear Medicine
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：28
- 期：9
- 页码：897-902
- 全文大小：909 KB
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17. Bennink RJ, Tulchinsky M, de Graaf W, Kadry Z, van Gulik TM. Liver function testing with nuclear medicine techniques is coming of age. Semin Nucl Med. 2012;42(2):124-7.- 作者单位：Dominik Geisel (1)
Lutz Lüdemann (3)
Bernhard Gebauer (1)
Vera Fr?ling (1)
Vikas Prasad (2)
Uwe Heimann (1) (2)
Martin Stockmann (4)
Maciej Malinowski (4)
Bernd Hamm (1)
Winfried Brenner (2)
Timm Denecke (1) (2)
1. Klinik für Radiologie, Campus Virchow-Klinikum, Charité, Universit?tsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
3. Department of Medical Physics, Essen University Hospital, Hufelandstra?e 55, 45147, Essen, Germany
2. Klinik für Nuklearmedizin, Campus Virchow-Klinikum, Charité, Universit?tsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
4. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Campus Virchow-Klinikum, Charité, Universit?tsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany- ISSN：1864-6433
- 作者单位：Dominik Geisel (1)
文摘
Objective To correctly display the left and right liver lobe separately on dynamic projection scintigraphy, it is essential to adjust the collimator to the angle of the plane between the two liver lobes. We propose an optimized protocol for separating left and right liver lobe in 99mTc-mebrofenin hepatobiliary scintigraphy in a hybrid SPECT-CT device. The protocol uses the inherent attenuation correction low-dose CT (AC-CT) for individually adjusting gamma camera head angulation. The results of this protocol are compared with hypothetical results based on previous MRI, fixed angle, and traditional frontal projection. Methods The absolute and relative degrees of overlapping volume between left and right liver lobe parenchyma for frontal projection, 45° right anterior oblique (RAO) projection, RAO angulation based on previously acquired MRI, and RAO based on the AC-CT were measured in 14 patients who underwent 99mTc-mebrofenin hepatobiliary scintigraphy. Results Relative degree of overlap was 31.3?±?15.2?% for frontal projection, 8.2?±?6.5?% for 45° RAO, 5.5?±?3.5?% for RAO based on previous MRI, and 3.6?±?2.5?% for RAO based on AC-CT. The relative overlap of RAO projections based on previous MRI was significantly lower than for frontal projection (p?p? Conclusions Performing 99mTc-mebrofenin hepatobiliary scintigraphy using RAO detector alignment with an angle derived from a prior CT obtained in the SPECT-CT scanner can significantly reduce the degree of overlap between right and left liver lobe. If SPECT-CT is not available, previous CT or MRI or a fixed angle of 45° may be used.