Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action

详细信息    查看全文

• 作者：S. Khazaei ; R. Abdul Hamid ; N. Mohd Esa…
• 关键词：Allium atroviolaceum ; HepG2 ; Apoptosis
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：2949KB
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882
• 卷排序：17

文摘

BackgroundLiver cancer is a high incidence and fatal disease, the fifth most frequent cancer worldwide that is usually diagnosed at an advanced stage. The number of deaths from liver cancer has not declined even following various therapies. Plant secondary metabolites and their semi-synthetic derivatives play a principal role in anti-cancer drug therapy, since they are effective in the treatment of specific characteristics while also reducing side effects. Allium atroviolaceum, a plant of the genus Allium has been used in folk medicine to protect against several diseases. However, cytotoxicity and the anti-proliferative effect of Allium atroviolaceum remain unclear. This work aims to investigate the anticancer properties of Allium atroviolaceum and the mechanism of action.