Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models

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• 作者：Celia Casares (1)
  Rafael Ramírez-Camacho (1)
  Almudena Trinidad (1)
  Amaya Roldán (1)
  Eduardo Jorge (2)
  José Ramón García-Berrocal (1)
  
• 关键词：Cisplatin ; Cochlea ; ROS ; Apoptosis ; Caspases ; Inflammation
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：269
• 期：12
• 页码：2455-2459
• 全文大小：215KB
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• 作者单位：Celia Casares (1)
  Rafael Ramírez-Camacho (1)
  Almudena Trinidad (1)
  Amaya Roldán (1)
  Eduardo Jorge (2)
  José Ramón García-Berrocal (1)
  
  1. Department of Otorhinolaryngology, Otology Research Group, University Hospital of Puerta de Hierro-Majadahonda, Manuel de Falla 1, Majadahonda, 28222, Madrid, Spain
  2. Department of Biochemistry, University Hospital of Puerta de Hierro-Majadahonda, Majadahonda, 28222, Madrid, Spain
  
• ISSN：1434-4726

文摘

Cisplatin is a highly effective chemotherapeutic agent but displays significant ototoxic side effects. The most prominent change seen in the cochlea after cisplatin administration consists of loss of outer hair cells. Several mechanisms are believed to mediate cisplatin-induced apoptosis: binding of cisplatin to guanine bases on DNA and the formation of inter- and intra-strand chain cross-linking, generation of reactive oxygen species (ROS) with increased lipid peroxidation and Ca2+ influx and, finally, inflammation mediated by cisplatin. The aim of the present review is to analyze the role of ROS in the mechanisms causing cisplatin-mediated apoptosis in the inner ear and the contribution of the different pathways involved, emphasizing the main strategies to blockade events leading to apoptosis of cochlear cells.