PinX1 inhibits cell proliferation, migration and invasion in glioma cells

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• 作者：Peng-Jin Mei (1) (2)
  Yan-Su Chen (1) (3)
  Ying Du (1)
  Jin Bai (1)
  Jun-Nian Zheng (1)
  
  1. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy ; Cancer Institute ; Xuzhou Medical College ; 84 West Huaihai Road ; Xuzhou ; 221002 ; Jiangsu Province ; China
  2. Department of Neurosurgery ; The Affiliated Hospital of Xuzhou Medical College ; 99 West Huaihai Road ; Xuzhou ; 221002 ; Jiangsu Province ; China
  3. School of Public Health ; Xuzhou Medical College ; 209 Tongshan Road ; Xuzhou ; 221002 ; Jiangsu Province ; China
  
• 关键词：PinX1 ; Proliferation ; Migration ; Invasion ; Gliomas
• 刊名：Medical Oncology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：32
• 期：3
• 全文大小：1,039 KB
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• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

PinX1 induces apoptosis and suppresses cell proliferation in some cancer cells, and the expression of PinX1 is frequently decreased in some cancer and negatively associated with metastasis and prognosis. However, the precise roles of PinX1 in gliomas have not been studied. In this study, we found that PinX1 obviously reduced the gliomas cell proliferation through regulating the expressions of cell cycle-relative molecules to arrest cell at G1 phase and down-regulating the expression of component telomerase reverse transcriptase (hTERT in human), which is the hardcore of telomerase. Moreover, PinX1 could suppress the abilities of gliomas cell wound healing, migration and invasion via suppressing MMP-2 expression and increasing TIMP-2 expression. In conclusion, our results suggested that PinX1 may be a potential suppressive gene in the progression of gliomas.