Phytochemical and pharmacological progress on the genus Syringa

详细信息    查看全文

• 作者：Guozhu Su (1) (2)
  Yuan Cao (1) (2)
  Chun Li (1)
  Xuelong Yu (1) (2)
  Xiaoli Gao (1)
  Pengfei Tu (1)
  Xingyun Chai (1)
  
  1. Modern Research Center for Traditional Chinese Medicine ; Beijing University of Chinese Medicine ; 11 North 3rd Ring Road ; Chaoyang District ; Beijing ; 100029 ; P. R. China
  2. School of Chinese Materia Medica ; Beijing University of Chinese Medicine ; 6 Wangjing Southern Middle Ring Road ; Chaoyang District ; Beijing ; 100102 ; P. R. China
  
• 关键词：Syringa ; Oleaceae ; Iridoid ; Lignan ; Phenylethanoid ; Bioactivities ; Review
• 刊名：Chemistry Central Journal
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：9
• 期：1
• 全文大小：1,105 KB
• 参考文献：1. Editorial Committee of Chinese Material Medica. Chinese Material Medica-Mongolian volume. Shanghai Sci Technol Press. 1992;61:2鈥?0.
  2. Zhang JF, Zhang SJ. An overview of the genus / Syringa: phytochemical and pharmacological aspects. Nat Sci J Hainan Univ. 2007;2:201鈥?.
  3. Deng RX, Yuan H, Liu P, Yin WP, Wang XS, Zhao TZ. Chemical constituents from / Syringa pubescens Turcz. Biochem Syst Ecol. 2010;38:813鈥?. 2010.08.004" target="_blank" title="It opens in new window">CrossRef
  4. Zhang GB, Liu LJ, Wang MK. Chemical constituents of volatile oils from / Syringa pinnatifolia. Chin Pharm J. 1994;5:271.
  5. SamyK ED, GamalEldeen AM. Cytotoxic and anti-inflammatory activities of some constituents from the floral buds of / Syringa patula. Pharm Biol. 2009;47:872鈥?. 200902950785" target="_blank" title="It opens in new window">CrossRef
  6. Dinda B, Debnath S, Harigaya Y. Naturally occurring iridoids. a review, part 1. Chem Pharm Bull. 2007;55:159鈥?22. 248/cpb.55.159" target="_blank" title="It opens in new window">CrossRef
  7. Ghisalberti EL. Biological and pharmacological activity of naturally occurring iridoids and secoiridoids. Phytomedicine. 1998;5:147鈥?3. 2-3" target="_blank" title="It opens in new window">CrossRef
  8. Oh H, Ko EK, Kim DH, Jang KK, Park SE, Lee HS, et al. Secoiridoid glucosides with free radical scavenging activity from the leaves of / Syringa dilatata. Phytother Res. 2003;17:417鈥?. 2/ptr.1148" target="_blank" title="It opens in new window">CrossRef
  9. Masafumi K, Yasunri Y, Nariyasu M. Glycoside from the leaves of / Syringa vulgaris and their growth inhibitory activity against human cancer cell lines. Japan Soc Pharm. 2010;64:104鈥?.
  10. Bi XY, Li W, Sasaki T, Li Q, Mitsuhata N, Asada Y, et al. Secoiridoid glucosides and related compounds from / Syringa reticulata and their anti-oxidant activities. Bioorg Med Chem Lett. 2011;21:6426鈥?. 2011.08.089" target="_blank" title="It opens in new window">CrossRef
  11. Kikuchi M, Yaoita Y, Mano N, Kikuchi M. Structure and cytotoxic activity of enzymatic hydrolysis products of secoiridoid glucosides, isoligustroside and isooleuropein. Chem Biodivers. 2011;8:651鈥?. 2/cbdv.201000092" target="_blank" title="It opens in new window">CrossRef
  12. Park HJ, Lee MS, Lee KT, Sohn IC, Han YN, Miyamoto K. Studies on constituents with cytotoxic activity from the stem bark of / Syringa velutina. Chem Pharm Bull. 1999;47:1029鈥?1. 248/cpb.47.1029" target="_blank" title="It opens in new window">CrossRef
  13. Yk T, Okazaki N, Tanahashi T, Nagakura N, Nishi T. Secoiridoid and iridoid glucosides from / Syringa afghanica. Phytochemistry. 2002;59:779鈥?7. 22(02)00024-9" target="_blank" title="It opens in new window">CrossRef
  14. Nenadis N, Vervoort J, Boeren S, Tsimidou MZ. / Syringa oblata Lindl var. / alba as a source of oleuropein and related compounds. J Sci Food Agr. 2007;87:160鈥?. 2/jsfa.2697" target="_blank" title="It opens in new window">CrossRef
  15. Kikuch IM, Yamauchi Y, Yanase C. Structures of new secoiridoid glycosides from the leaves of / Syringa vulgaris Linn. Yakugakuzasshi. 1987;107:245鈥?.
  16. Machida K, Kaneko A, Hosogai T, Kakuda R, Yaoita Y, Kikuchi M. Studies on the constituents of / Syringa species. X. five new iridoid glycosides from the leaves of / Syringa reticulata (Blume) Hara. Chem Pharm Bull. 2002;50:493鈥?. 248/cpb.50.493" target="_blank" title="It opens in new window">CrossRef
  17. Sticher O, Ahmad M, Salama O, Winkler T. Two new secoiridoid glucosides from / Syringa vulgaris. Planta Med. 1982;45:151. 2007-971324" target="_blank" title="It opens in new window">CrossRef
  18. Kikuch IM, Yamauchi Y, Takahashi Y. Structures of new secoiridoid glycosides from the leaves of / Syringa vulgaris Linn. Yakugakuzasshi. 1988;108:355鈥?0.
  19. Machida K, Unagami E, Ojima H, Kikuchi M. Studies on the constituents of / Syringa species. XII. new glycosides from the leaves of / Syringa reticulata (Blume) Hara. Chem Pharm Bull. 2003;51:883鈥?. 248/cpb.51.883" target="_blank" title="It opens in new window">CrossRef
  20. Garcia J, Lavaitte S, Gey C. 8-Epikingiside and its vanillate ester, isolated from / Gentiana pyrenaica. Phytochemistry. 1989;28:2199鈥?01. 22(00)97944-5" target="_blank" title="It opens in new window">CrossRef
  21. Feng XS, Qu Y, Wu ZHXL, Zhang DS, Gao HY, Wu LJ. Two new secoiridoid glucosides from / Syringa velutina Kom. Chinese Chem Lett. 2009;20:702鈥?. 2009.02.012" target="_blank" title="It opens in new window">CrossRef
  22. Asaka Y, Kamikawa T, Tokoroyama T, Kubota T. The structure and absolute configuration of syringopicroside. a new iridoid glucoside from / Syringa vulgaris. Tetrahedron. 1970;26:2365鈥?0. 20(01)92815-7" target="_blank" title="It opens in new window">CrossRef
  23. Zhou YM, Gao HY, Wu B, Li SH, Wu LJ. Structure determination of syringopicroside from the leaves of / Syringa oblata Lindl. using 2D NMR spectral methods. Asian J Tradit Med. 2006;1:31鈥?.
  24. Zhang SJ, Guo HQ, Han J, Zhao M, Wang JJ. Chemical constituents from seeds of / Syringa oblata. Chin Tradit Herbal Drugs. 2011;42:1894鈥?00.
  25. Wang JL, Zhang GF, Dong LW, Zhao M, Zhang SJ. Chemical constituents from seed crust of / Syringa oblata. Chin Tradit Herbal Drugs. 2010;41:1598鈥?01.
  26. Kikuch IM, Yamauchi Y, Takahashi Y. Studies on constituents of / Syringa species. VIII. Isolation and structures of phenylpropanoid glycosides from the leaves of / Syringa reticulata (Blume) Hara. Yakugakuzasshi. 1989;109:366鈥?1.
  27. Luo Y, Liu Y, Qi H, Wu Z, Zhang G. Steryl esters and phenylethanol esters from / Syringa komarowii. Steroids. 2006;71:700鈥?. 2006.04.004" target="_blank" title="It opens in new window">CrossRef
  28. Feng XS, Qu Y, Xu L, Wang DC, Wu LJ, Meng FH, et al. Two new neolignans from / Syringa velutina Kom. Molecules. 2009;14:953鈥?. CrossRef
  29. Kurkin VA. Phenylpropanoids from medicinal plants: distribution, classification, structural analysis, and biological activity. Chem Nat Compd. 2003;39:123鈥?3. 23/A:1024876810579" target="_blank" title="It opens in new window">CrossRef
  30. Zeng XJ, Wang GC, Wu X, Li YL. Chemical constituents from / Syringa pinnatifolia. Chin Tradit Herbal Drugs. 2013;7:1721鈥?.
  31. Ao WLJ, Bao XH, Wu XL, Wang QH. Lignans from / Syringa pinnatifolia var. / alashanensis. J Asian Nat Prod Res. 2012;14:396鈥?00. 286020.2012.656606" target="_blank" title="It opens in new window">CrossRef
  32. Xu QM, Li Q, Liu YL, Feng YL, Yang SL, Li XR. New lignans from / Syringa reticulata var. / mandshurica. Chem Nat Compd. 2010;46:366鈥?. CrossRef
  33. Wang QH, Ao WLJ, Wu QS, Ying X. Two new neolignans from the stems of / Syringa pinnatifolia var. / alashanensis. Helv Chim Acta. 2012;95:1680鈥?. 2/hlca.201200118" target="_blank" title="It opens in new window">CrossRef
  34. Ao WLJ, Wang QH, Wang XL, Dai YNT. Extraction and structure elucidation of three lignans from peeled dried roots and stems of / Syringa pinnatifolia. Chin Tradit Herbal Drugs. 2013;7:791鈥?.
  35. Machida K, Ohkawa N, Ohsawa A, Kikuchi M. Two new phenolic glycosides from / Syringa reticulata. J Nat Med. 2009;63:192鈥?. 295-3" target="_blank" title="It opens in new window">CrossRef
  36. Ahmad M, Rizwan GH, Aftab K, Ahmad VU, Gilani AH, Ahmad SP. Acteoside: a new antihypertensive drug. Phytother Res. 1995;9:525鈥?. 2/ptr.2650090713" target="_blank" title="It opens in new window">CrossRef
  37. Ao WLJ, Wang QH, Si Q, Mu D, Sa RTY, Dai NYT, et al. The structural elucidation and antimicrobial activities of two new sesquiterpenes from / Syringa pinnatifolia. Chin J Nat Med. 2012;10:477鈥?0.
  38. Li ZG, Lee MR, Shen DL. Analysis of volatile compounds emitted from fresh / Syringa oblata flowers in different florescence by headspace solid-phase microextraction-gas chromatography鈥搈ass spectrometry. Anal Chim Acta. 2006;1:43鈥?. 2006.01.074" target="_blank" title="It opens in new window">CrossRef
  39. Chen XZ, Liang YZ, Fang HZ, Li XN. Temperature-programmed retention indices for gas chromatography-mass spectroscopy analysis of plant essential oils. J Chromatogr A. 2005;1096:76鈥?5. 2005.09.067" target="_blank" title="It opens in new window">CrossRef
  40. Yu AN, Yang XZ. Chemical composition of the essential oil of fresh wild / Syringa pubescens flowers from China. Adv MaterRes (Durnten-Zurich, Switzerland). 2012;22:581鈥?.
  41. Kikuch IM, Yamauchi Y. Studies the constituents of / Syringa species. I. Isolation and structures of iridiods and secoiridoids from the leaves of / Syringa reticulata (Blume) Hara. Yakugakuzasshi. 1987;107:350鈥?.
  42. Ahmad M, Salama O, Sticher O. Isolation of echinacoside from the white flowers of / Syringa vulgaris. J Chem Soc Pakistan. 1987;9:451鈥?.
  43. Xu QM, Liu YL, Li XR, Feng YL, Yang SL. Two new phenylglycol derivatives isolated from / Syringa reticulata var. / mandshurica and their antifungal activities. Chem Pharm Bull. 2009;57:863鈥?. 248/cpb.57.863" target="_blank" title="It opens in new window">CrossRef
  44. Ao WLJ, Wang QH, Dai YNT. Chemical detection on the stems of / Syringa pinnatifolia var. / alashanensis. Chin Hosp Pharm J. 2013;33:1544鈥?.
  45. Kurkin VA. Phenylpropanoids as the biologically active compounds of the medicinal plants and phytopharmaceuticals. Adv Biol Chem. 2013;3:26鈥?. 236/abc.2013.31004" target="_blank" title="It opens in new window">CrossRef
  46. Ahmad M, Aftab K. Hypotensive action of syringin from / Syringa vulgaris. Phytother Res. 1995;9:452鈥?. 2/ptr.2650090614" target="_blank" title="It opens in new window">CrossRef
  47. Kikuch IM, Yamauchi Y. Studies on constituents of / Syringa species I. Isolation and structure of iridodids and secoiridoids from the leaves of / Syringa reticulata (Blume) Hara. Yakugakuzasshi. 1987;107:23鈥?.
  48. Kurkin VA, Zapesochnaya GG, Ginenko NA, Zolotarev BM. Phenolic compounds from the bark of / Syringa vulgaris. Chem Nat Compd. 1989;4:581鈥?.
  49. Ahmad M, Salama O. Flavonoids from violet flowers of / Syringa vulgaris. Pakistan J Sci Ind Res. 1987;30:150鈥?.
  50. Ahmad M, Salama O. Isolation of rutin from the fresh leaves of / Syringa vulgaris. J Pharm. 1985;4:9鈥?1.
  51. Yin WP, Zhao TZ, Zhang HY. A novel oligosaccharide ester from / Syringa pubescens. J Asian Nat Prod Res. 2008;10:95鈥?00. 286020701394241" target="_blank" title="It opens in new window">CrossRef
  52. Helmut R. Jasminidin, ein neues monoterpenalklaloid aus / Syringa vulgaris. Phytochemistry. 1978;17:1069鈥?0. 22(00)94288-2" target="_blank" title="It opens in new window">CrossRef
  53. Liu X, Wang JM. Iridoid glycosides fraction of Folium Syringae leaves modulate NF-魏B signal pathyway and intestinal epithelial cells apoptosis in experimental colitis. Plos One. 2011;6:e24740. 24740" target="_blank" title="It opens in new window">CrossRef
  54. Liu X, Wang JM. Anti-inflammatory effects of iridoid glycosides fraction of / Folium Syringae leaves on TNBS-induced colitis in rats. J Ethnopharmacol. 2011;133:780鈥?. 2010.11.010" target="_blank" title="It opens in new window">CrossRef
  55. Gao SQ, Niu JQ, Wang F, Wang F, Liu XD, Jin ZX, et al. Comparative studies on the resistance of hepatitis B by / Syringa extract, IFN and ganyanling in HepG2.2.15 cells. Chin J Cell Mol Immunol. 2003;19:385鈥?.
  56. Yao DL, Han ZG, Zhou W, Ju GM, Li G. Protective effects of the / Syringa reticulata var. / mandshurica extract against acute liver injury in mice. J Med Sci Yan B Univ. 2009;32:29鈥?1.
  57. Li JX. The / Syringa aramaticum modern pharmacological research. P J Pract Tradit Chin Med. 2002;18:54.
  58. Yan Y, WLJ O, Zhao XJ, Ye XC, Zhang C, Hao JJ, et al. Effect of essential oil of / Syringa pinnatifolia var. / alashanensis on ischemia of myocardium, hypoxia and platelet aggregation. J Ethnopharmacol. 2010;131:248鈥?5. 2010.06.027" target="_blank" title="It opens in new window">CrossRef
  59. Balint G, Eperjessy ET, Thuranszky K. Hypothermic action of the leaf extract of / Syringa vulgaris. Acta Physiolo Acad Sci Hung. 1965;28:399鈥?06.
  60. Yang WW, Xing MY. The preparations of / Syringa oblata leaves change in immunoassay after the treatment on herpes simplex keratitis. Chin J Pract Ophthalmolol. 1990;8:252鈥?1.
  61. Xing MY. The preparations of / Syringa oblata leaves change in tears鈥?PH after the treatment on herps simplex keratitis. Chin J Ophthalmolol. 1992;10:312鈥?1.
  62. Xing MY, Li B. The preparations of / Syringa oblata leaves treat epidemic hermorrhagic conjunctivitis. Chin J Ophthalmolol. 1996;14:301.
  63. Li SJ, Xu LY. The preparations of / Syringa oblata leaves treat hemorrhoids with 18 cases. China Acad J. 2001;1:57.
  
• 刊物类别：Chemistry and Materials Science
• 出版者：Chemistry Central Ltd
• ISSN：1752-153X

文摘

Genus Syringa, belonging to the Oleaceae family, consists of more than 40 plant species worldwide, of which 22 species, including 18 endemic species, are found in China. Most Syringa plants are used in making ornaments and traditional medicines, whereas some are employed for construction or economic use. Previous studies have shown that extracts of Syringa plants mainly contain iridoids, lignans, and phenylethanoids that have antitumor, antihypertensive, anti-oxidant, and anti-inflammatory activities. This study reviews phytochemical and pharmacological progress on Syringa in the recent 20 years and discusses the future research prospects to provide a reference in further promotion and application of the genus. Graphical Abstract Phytochemical and pharmacological progress on the genus Syringa