Segmental differences in the orientation of smooth muscle cells in the tunica media of porcine aortae

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• 作者：Zbynek Tonar (1)
  Petra Kochova (1)
  Robert Cimrman (2)
  Josef Perktold (3)
  Kirsti Witter (4)
  
  1. NTIS ; European Centre of Excellence ; Faculty of Applied Sciences ; University of West Bohemia ; Univerzitn铆 22 ; 306聽14聽 ; Plze艌 ; Czech Republic
  2. New Technologies - Research Centre ; University of West Bohemia ; Univerzitn铆 8 ; 306聽14聽 ; Plze艌 ; Czech Republic
  3. 156 Avenue Willowdale ; Outremont ; QC ; H3T1E9 ; Canada
  4. Department of Pathobiology ; Institute of Anatomy ; Histology and Embryology ; University of Veterinary Medicine Vienna ; Veterin盲rplatz聽1 ; 1210聽 ; Vienna ; Austria
  
• 关键词：Von Mises distribution ; Thoracic aorta ; Abdominal aorta ; Pig ; Swine ; Blood vessel
• 刊名：Biomechanics and Modeling in Mechanobiology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：14
• 期：2
• 页码：315-332
• 全文大小：4,032 KB
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• 刊物类别：Engineering
• 刊物主题：Theoretical and Applied Mechanics
  Biomedical Engineering
  Mechanics
  Biophysics and Biomedical Physics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1617-7940

文摘

The orientation of vascular smooth muscle cells of porcine aortae was assessed to test the widely accepted assumption that these smooth muscle cells are arranged in two helices. We used tangential histological sections of 82 samples of five anatomical segments of thoracic and abdominal porcine aortae and three age groups in animals ranging in age from 5 to 210 days. The distribution of the orientation of smooth muscle cell nuclei in five proximodistal segments of the porcine aortae was determined using an algorithm that fitted a mixture of one to five von Mises probability distributions of the data retrieved from histological micrographs. Automated tracking of the nuclei was confirmed by and consistent with manual histological analysis. The orientation of the vascular smooth muscle cells was successfully fitted using two von Mises distributions in most of the samples with different ages, wall thicknesses, and anatomical positions, which corresponds to two populations of vascular smooth muscle cells. A minor fraction of samples also required a tertiary von Mises distribution to describe the orientation of the smooth muscle cell nuclei. The distribution of vascular smooth muscle cells in five aortic segments ranging from the thoracic ascending aorta to the abdominal intrarenal aorta exhibited similar main directions but different shapes. These results are consistent with the widely used model of two muscular helices intermingling in the arterial wall. Furthermore, we calculated the central angles of symmetry and the mean value of angles between the two assumed smooth muscle directions. We also successfully approximated the orientation of the smooth muscle cells using a mixture of von Mises distributions and our open-source software named dist_mixtures. This method is openly available to researchers who are interested in mathematically assessing the orientation of cell nuclei in various tissues.