Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth

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• 作者：Yin-Hsiu Chen ; Kelly K Ferguson ; John D Meeker ; Thomas F McElrath…
• 关键词：Prematurity ; Environment ; Statistical methods ; Biomarkers ; Repeated measures
• 刊名：Environmental Health
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：14
• 期：1
• 全文大小：710 KB
• 刊物主题：Environmental Health; Occupational Medicine/Industrial Medicine; Public Health;
• 出版者：BioMed Central
• ISSN：1476-069X

文摘

Background It is of critical importance to evaluate the role of environmental chemical exposures in premature birth. While a number of studies investigate this relationship, most utilize single exposure measurements during pregnancy in association with the outcome. The studies with repeated measures of exposure during pregnancy employ primarily cross-sectional analyses that may not be fully leveraging the power and additional information that the data provide.