Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology

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• 作者：Ehsan Hosseini (1)
  Behnam Pedram (2)
  Ali Mohammad Bahrami (1)
  Seyed Rashid Touni (3)
  Hamed Zamankhan Malayeri (4)
  Aram Mokarizadeh (5)
  Mehdi Pourzaer (6)
  Maryam Pourzaer (7)
  Shahram Zehtabian (8)
  Sheida Mohajer (9)
  Sharareh Ahmadi (10)
  
  1. Faculty of Para Veterinary Medicine ; Ilam University ; Ilam ; Iran
  2. Department of Pathobiology ; Susangerd Branch ; Islamic Azad University ; Susangerd ; Iran
  3. Department of Basic Science ; Faculty of Veterinary Medicine ; Urmia University ; Urmia ; Iran
  4. Department of Internal Medicine ; Faculty of Veterinary Medicine ; Tehran University ; Tehran ; Iran
  5. Department of Immunology ; Faculty of Medicine ; and Cellular and Molecular Research Center ; Kurdistan University of Medical Sciences ; Sanandaj ; Iran
  6. Faculty of Veterinary Science ; Karaj Branch ; Islamic Azad University ; Alborz ; Iran
  7. Department of Biology ; Faculty of Basic Science ; Damghan Branch ; Islamic Azad University ; Damghan ; Iran
  8. Department of Microbiology ; Faculty of Medicine ; Kermanshah University of Medical Sciences ; Kermanshah ; Iran
  9. Chronic Respiratory Disease Research Center ; National Research Institue of Tuberculosis and Lung Diseases ; Massih Daneshvary Hospital ; Shahid Beheshti University of Medicine ; Tehran ; Iran
  10. Faculty of Medicine ; Kermanshah University of Medical Sciences ; Kermanshah ; Iran
  
• 关键词：Immunohistochemistry ; Histopathology ; KIT ; Neoplasia ; Uterine ; Liver
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：2
• 页码：929-937
• 全文大小：2,242 KB
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• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The activating KIT marker plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). Recent studies have identified the KIT (CD117) as a marker that distinguishes nonneoplastic from neoplastic mast cells in human systemic mastocytosis. In this study, we conclude that immunohistopathology assays for KIT staining pattern are useful complimentary tools for diagnosis and evaluation of prognosis in uterus mast cell tumor (MCT) metastasis to the liver in 10 patients. Uterine and hepatic cytology revealed mast cell neoplasia, which was confirmed as visceral mast cell tumor on postmortem examination. Histological changes of densely packed, poorly differentiated neoplastic mast cells, sheets of neoplastic round to pleomorphic cells that formed nonencapsulated nodules, high mitotic figures, necrosis, and fibrosis were found. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. These findings indicate tumors of high-grade malignancy with infiltrative cells resembling the uterus MCT in the intraparenchymal and periparenchymal areas of the liver. Immunohistochemically, tumors were positive for KIT. The histopathologic features coupled with the KIT immunoreactivity led to diagnosis of high-grade uterus MCTs. Taken together, these findings suggest that CD117 may play a critical role in early uterus MCT development and may be a stimulatory factor in grade 3 MCT. Therefore, the result has supported our hypothesis that there was an increased opportunity to observe a higher CD117 staining pattern in high-grade MCTs.