Optimized Conformal Paraaortic Lymph Node Irradiation is not Associated with Enhanced Renal Toxicity
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- 作者：Meinhard Nevinny-Stickel ; Karin Poljanc ; Britta C. Forthuber ; Dirk Heute ; Andrea Posch ; Judith Lechner ; Beate Beer ; Peter Lukas and Thomas Seppi
- 关键词：Key Words ; Paraaortic lymph node irradiation ; Radiation ; induced nephropathy ; Dynamic renal scintigraphy
- 刊名：Strahlentherapie und Onkologie
- 出版年：2007
- 出版时间：July, 2007
- 年：2007
- 卷：183
- 期：7
- 页码：385-391
- 全文大小：440 KB
文摘
Background and Purpose: For patients with gynecologic carcinomas, irradiation of paraaortic lymph nodes (PLNs) is a routine treatment concept. Planning target volumes (PTVs) individually optimized by radiation field delineations along the big vessels permit the inclusion of at least 97 % of potentially involved PLNs. However, this novel treatment technique might increase radiation-induced nephrotoxicity. Therefore, the actual incidence of kidney damage after PLN irradiation has to be assessed in order to validate the safety of this treatment concept.