LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins

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• 作者：Meixiang Sang (1) (2)
  Li Ma (2)
  Meijie Sang (1) (4)
  Xinliang Zhou (3)
  Wei Gao (2)
  Cuizhi Geng (2)
  
• 关键词：LIM domain ; LMO ; Gene transcription ; LDB1 ; Protein–protein interaction
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：41
• 期：2
• 页码：1067-1073
• 全文大小：356 KB
• 作者单位：Meixiang Sang (1) (2)
  Li Ma (2)
  Meijie Sang (1) (4)
  Xinliang Zhou (3)
  Wei Gao (2)
  Cuizhi Geng (2)
  
  1. Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, People’s Republic of China
  2. Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, People’s Republic of China
  4. Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan
  3. Department of Chemotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, People’s Republic of China
  
• ISSN：1573-4978

文摘

The LIM-only subclass of LIM proteins is a family of nuclear transcription co-regulators that are characterized by the exclusive presence of two tandem LIM domains and no other functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified. They regulate gene transcription by functioning as “linker-or “scaffolding-proteins with a remarkable potential to mediate protein–protein interactions. These proteins play important roles in cell fate determination, cell growth and differentiation, tissues patterning, and organ development. In this review, we briefly described the functions of LMO proteins in the organ development and diseases. We also summarized the interaction proteins of each LMO family member, which may contribute to elucidating the functions of these mysterious and important linker proteins.