First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

详细信息    查看全文

• 作者：Wolfgang Huber ; Benedikt Henschel ; Roland Schmid ; Ahmed Al-Chalabi
• 关键词：Chronic liver failure ; Acute ; on ; chronic ; liver failure ; Acute liver failure ; Extracorporeal liver support ; Liver transplantation ; Single pass albumin dialysis ; Molecular Adsorbent Recirculating System ; Fractionated plasma separation and adsorption ; CLIF ; SOFA ; MELD
• 刊名：BMC Gastroenterology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：602KB
• 刊物主题：Gastroenterology; Internal Medicine; Hepatology;
• 出版者：BioMed Central
• ISSN：1471-230X
• 卷排序：17

文摘

BackgroundLiver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing concept to “bridge to transplant” or to avoid transplant in case of recovery. ADVanced Organ Support (ADVOS) is a new type of albumin dialysis, that provides rapid regeneration of toxin-binding albumin by two purification circuits altering the binding capacities of albumin by biochemical (changing of pH) and physical (changing of temperature) modulation of the dialysate.