The influence of body weight on the pulmonary oxygen uptake kinetics in pre-pubertal children during moderate- and heavy intensity treadmill exercise
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- 作者：Danielle Lambrick (1)
James Faulkner (2)
Nicole Westrupp (2)
Melitta McNarry (3) - 关键词：Paediatric ; Oxygen uptake ; Obese ; Moderate intensity exercise ; Heavy intensity exercise
- 刊名：European Journal of Applied Physiology
- 出版年：2013
- 出版时间：August 2013
- 年：2013
- 卷：113
- 期：8
- 页码：1947-1955
- 全文大小：317KB
- 参考文献：1. Armstrong N, Fawkner S (2007) Aerobic fitness. In: Armstrong N (ed) Paediatric exercise science. Churchill Livingstone Elsevier, Philadelphia, pp 161-87 CrossRef
2. Barker AR, Williams CA, Jones AM, Armstrong N (2009) Establishing maximal oxygen uptake in young people during a ramp cycle test to exhaustion. Br J Sports Med 45:498-03. doi:10.1136/bjsm.2009.063180 CrossRef
3. Barstow TJ, Mole PA (1991) Linear and nonlinear characteristics of oxygen-uptake kinetics during heavy exercise. J Appl Physiol 71:2099-106
4. Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas-exchange. J Appl Physiol 60:2020-027
5. Behnke BJ, McDonough P, Padilla DJ, Musch TI, Poole DC (2003) Oxygen exchange profile in rat muscles of contrasting fibre types. J Physiol 549:597-05. doi:10.1113/jphysiol.2002.035915 CrossRef
6. Carter BJ, Jones AM, Barstow TJ, Burnley M, Williams CA, Doust JH (2000) Oxygen uptake kinetics in treadmill running and cycle ergometry: a comparison. J Appl Physiol 89:899-07
7. Carter H, Pringle J, Jones A, Doust J (2002) Oxygen uptake kinetics during treadmill running across exercise intensity domains. Eur J Appl Physiol 86:347-54 CrossRef
8. Chen A (2012) On childhood obesity prevention: exercise is medicine vs. exercise is vaccine. J Sport Health Sci 1:172-73. doi:10.1016/j.jshs.2012.07.008 CrossRef
9. Cleuziou C, Lecoq AM, Candau R, Courteix D, Guenon P, Obert P (2002) Kinetics of oxygen uptake at the onset of moderate and heavy exercise in trained and untrained prepubertal children. Sci Sports 17:291-96. doi:10.1016/S0765-1597(02)00169-7 CrossRef
10. Cole T, Lobstein T (2012) Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes 7:284-94. doi:10.1111/j.2047-6310.2012.00064.x CrossRef
11. Cooper DM, Poage J, Barstow TJ, Springer C (1990) Are obese children truly unfit? Minimizing the confounding effect of body size on the exercise response. J Pediatr 116:223-30. doi:10.1016/S0022-3476(05)82878-1 CrossRef
12. Coyle EF, Sidossis LS, Horowitz JF, Beltz JD (1992) Cycling efficiency is related to the percentage of type I muscle fibers. Med Sci Sports Exerc 24:782-88
13. Crow MT, Kushmerick MJ (1982) Chemical energetics of slow-twitch and fast-twitch muscles of the mouse. J Gen Physiol 79:147-66 CrossRef
14. Day JR, Rossiter HB, Coats EM, Skasick A, Whipp BJ (2003) The maximally attainable / VO2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol 95:1901-907. doi:10.1152/japplphysiol.00024.2003
15. Fawkner S, Armstrong N (2003) Oxygen uptake kinetic response to exercise in children. Sports Med 33:651-69 CrossRef
16. Fawkner S, Armstrong N (2004) Modelling the / VO2 kinetic response to heavy intensity exercise in children. Ergonomics 47:1517-527 CrossRef
17. Fawkner S, Armstrong N (2007) Can we confidently study / VO2 kinetics in young people? J Sport Sci Med 6:277-85
18. Franks P, Hanson R, Knowler W, Sievers M, Bennett P, Looker H (2010) Childhood obesity, other cardiovascular risk factors, and premature death. New Engl J Med 362:485-93. doi:10.1056/NEJMoa0904130 CrossRef
19. Gidding S, Nehgme R, Heise C, Muscar C, Linton A, Hassink S (2004) Severe obesity associated with cardiovascular deconditioning, high prevalence of cardiovascular risk factors, diabetes mellitus/hyperinsulinemia, and respiratory compromise. J Pediatr 144:766-69. doi:10.1016/S0022-3476(04)00243-4
20. Grassi B (2005) Delayed activation of oxidative phosphorylation in skeletal muscle at exercise onset. Med Sci Sports Exerc 37:1567-573 CrossRef
21. Grassi B (2006) Oxygen uptake kinetics: why are they so slow? What do they tell us? J Physiol Pharmacol 57:53-5
22. Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD (1996) Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80:988-98
23. Grassi B, Hogan MC, Greenhaff PL, Hamann JJ, Kelley KM, Aschenbach WG, Constantin-Teodosiu D, Gladden LB (2002) Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol 538:195-07. doi:10.1113/jphysiol.2001.012984 CrossRef
24. Grassi B, Porcelli S, Salvadego D, Zoladz JA (2011) Slow / VO2 kinetics during moderate intensity exercise as markers of lower metabolic stability and lower exercise tolerance. Eur J Appl Physiol 111:345-55 CrossRef
25. Hebestreit H, Hebestreit A, Trusen A, Hughson R (2005) Oxygen uptake kinetics are slowed in cystic fibrosis. Med Sci Sports Exerc 37:10-7. doi:10.1249/01.mss.0000150065.97657.7b CrossRef
26. Jones AM, Doust JH (1996) A 1% treadmill grade most accurately reflects the energetic cost of outdoor running. J Sports Sci 14:321-27. doi:10.1080/02640419608727717 CrossRef
27. Jones AM, Poole DC (2005) Oxygen uptake kinetics in sport. Exercise and Medicine, Routledge
28. Jones AM, Wilkerson DP, Koppo K, Wilmshurst S, Campbell IT (2003) Inhibition of nitric oxide synthase by l-NAME speeds phase II pulmonary / VO2 kinetics in the transition to moderate-intensity exercise in man. J Physiol 552:265-72. doi:10.1113/jphysiol.2003.045799 CrossRef
29. Jones AM, Wilkerson DP, Wilmshurst S, Campbell IT (2004) Influence of l-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise. J Appl Physiol 96:1033-038. doi:10.1152/japplphysiol.00381.2003 CrossRef
30. Koppo K, Bouckaert J, Jones AM (2004) Effects of training status and exercise intensity on phase II / VO2 kinetics. Med Sci Sports Exerc 36:225-32 CrossRef
31. Kriketos A, Baur L, O’Connor J, Carey D, King S, Caterson I, Storlien L (1997) Muscle fibre type composition in infant and adult populations and relationships with obesity. Int J Obes Relat Metab Disord 21:796-01. doi:10.1038/sj.ijo.0800476 CrossRef
32. Krustrup P, Secher NH, Relu MU, Hellsten Y, Soderlund K, Bangsbo J (2008) Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. J Physiol 586:6037-048. doi:10.1113/jphysiol.2008.158162 CrossRef
33. Krustrup P, Jones A, Wilkerson D, Calbet J, Bangsbo J (2009) Muscular and pulmonary O2 uptake kinetics during moderate- and high-intensity sub-maximal knee-extensor exercise in humans. J Physiol 587:1843-856. doi:10.1113/jphysiol.2008.166397 CrossRef
34. Lamarra N, Whipp BJ, Ward SA, Wasserman K (1987) Effect of interbreath fluctuations on characterising exercise gas exchange kinetics. J Appl Physiol 62:2003-012 CrossRef
35. Lambrick D, Rowlands A, Eston R (2011) The perceptual response to treadmill exercise using the Eston–Parfitt scale and marble dropping task, in children age 7 to 8?years. Pediatr Exerc Sci 23:36-8
36. Lee S, Hidler J (2008) Biomechanics of overground vs. treadmill walking in healthy individuals. J Appl Physiol 107:747-55 CrossRef
37. Loftin M, Heusel L, Bonis M, Carlisle L, Sothern M (2005) Comparison of oxygen uptake kinetics and oxygen deficit in severely overweight and normal weight adolescent females. J Sports Sci Med 4:430-36
38. Marwood S, Roche D, Rowland TW, Garrard M, Unnithan V (2010) Faster pulmonary oxygen uptake kinetics in trained versus untrained male adolescents. Med Sci Sport Exerc 42:127-34 CrossRef
39. McDonough P, Behnke BJ, Padilla DJ, Musch TI, Poole DC (2005) Control of microvascular oxygen pressures in rat muscles comprised of different fibre types. J Physiol 563:903-13. doi:10.1113/jphysiol.2004.079533 CrossRef
40. McNarry MA, Welsman JR, Jones AM (2010) Influence of training status and exercise modality on pulmonary O2 uptake kinetics in pubertal girls. Eur J Appl Physiol 111:621-31. doi:10.1007/s00421-010-1681-6 CrossRef
41. McNarry MA, Kingsley MIC, Lewis MJ (2012) The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults. Am J Physiol Regul Integr Comp Physiol. doi:10.1152/ajpregu.00203.2012
42. Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, Reusch JEB, Regensteiner JG (2009) Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocr Metab 94:3687-695. doi:10.1210/jc.2008-2844 CrossRef
43. Obert P, Cleuziou C, Candau R, Courteix D, Lecoq AM, Guenon P (2000) The slow component of O2 uptake kinetics during high-intensity exercise in trained and untrained prepubertal children. Int J Sports Med 21:31-6. doi:10.1055/s-2000-8856 CrossRef
44. Poole DC, Jones AM (2012) Oxygen uptake kinetics. Compr Physiol 2:933-96. doi:10.1002/cphy.c100072
45. Poole DC, Schaffartzik W, Knight DR, Derion T, Kennedy B, Guy HJ, Prediletto R, Wagner PD (1991) Contribution of excising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol 71:1245-260
46. Poole DC, Barstow TJ, McDonough P, Jones AM (2008) Control of oxygen uptake during exercise. Med Sci Sports Exerc 40:462-74. doi:10.1249/MSS.0b013e31815ef29b CrossRef
47. Potter CR, Zakrzewski JK, Draper SB, Unnithan VB (2013) The oxygen uptake kinetic response to moderate intensity exercise in overweight and non-overweight children. Int J Obes 37:101-06 CrossRef
48. Reilly JJ, Methven E, McDowell ZC, Hacking B, Alexander D, Stewart L, Kelnar CJH (2003) Health consequences of obesity. Arch Dis Child 88:748-52. doi:10.1136/adc.88.9.748 CrossRef
49. Rossiter HB (2011) Exercise: kinetic considerations for gas exchange. Compr Physiol 1:203-44. doi:10.1002/cphy.c090010
50. Rossiter HB, Ward SA, Kowalchuk JM, Howe FA, Griffiths JR, Whipp BJ (2001) Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. J Physiol 537:291-03 CrossRef
51. Salvadego D, Lazzer S, Busti C, Galli R, Agosti F, Lafortuna C, Sartorio A, Grassi B (2010) Gas exchange kinetics in obese adolescents. Inferences on exercise tolerance and prescription. Am J Physiol Regul Integr Comp Physiol 299:R1298–R1305. doi:10.1152/ajpregu.00038.2010 CrossRef
52. Singh AS, Mulder C, Twisk JWR, Van Mechelen W, Chinapaw MJM (2008) Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev 9:474-88. doi:10.1111/j.1467-789X.2008.00475.x CrossRef
53. Unnithan VB, Baynard T, Potter CR, Barker P, Heffernan KS, Kelly E, Yates G, Fernhall B (2007) An exploratory study of cardiac function and oxygen uptake during cycle ergometry in overweight children. Obesity 15:2673-682. doi:10.1038/oby.2007.319 CrossRef
54. Welsman J, Armstrong N (2000) Statistical techniques for interpreting body size-related exercise performance during growth. Pediatr Exerc Sci 12:112-27
55. Whipp BJ, Rossiter HB (2005) The kinetics of oxygen uptake: physiological inferences from the parameters. In: Jones AM, Poole DC (eds) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, London
56. Whipp BJ, Wasserman K (1972) Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 33:351-56
57. Whipp BJ, Davis JA, Torres F, Wasserman K (1981) A test to determine parameters of aerobic function during exercise. J Appl Physiol 50:217-21
58. Wilkerson DP, Koppo K, Barstow TJ, Jones AM (2004) Effect of work rate on the functional ‘gain-of phase II pulmonary O2 uptake response to exercise. Respir Physiol Neuro 142:211-23 CrossRef
59. Winlove MA, Jones AM, Welsman J (2010) Influence of training status and exercise modality on pulmonary O2 uptake kinetics in pre-pubertal girls. Eur J Appl Physiol 108:1169-179. doi:10.1007/s00421-009-1320-2 CrossRef
60. World Health Organisation (2012) Prioritizing areas for action in the field of population-based prevention of childhood obesity. WHO Document Production Services, Geneva - 作者单位：Danielle Lambrick (1)
James Faulkner (2)
Nicole Westrupp (2)
Melitta McNarry (3)
1. Institute of Food, Nutrition and Human Health, Massey University, 63 Wallace Street, Mt Cook, Wellington, 6021, New Zealand
2. School of Sport and Exercise, Massey University, Wellington, New Zealand
3. Applied Sports, Technology, Exercise and Medicine Research Centre, College of Engineering, Swansea University, Swansea, UK
文摘
To assess the influence of obesity on the oxygen uptake ( $ \dot{V}{\text{O}}_{ 2} $ ) kinetics of pre-pubertal children during moderate- and heavy intensity treadmill exercise. We hypothesised that obese (OB) children would demonstrate significantly slower $ \dot{V}{\text{O}}_{ 2} $ kinetics than their normal weight (NW) counterparts during moderate- and heavy intensity exercise. 18 OB (9.8?±?0.5?years; 24.1?±?2.0?kg?m2) and 19 NW (9.7?±?0.5?years; 17.6?±?1.0?kg?m2) children completed a graded-exercise test to volitional exhaustion and two submaximal constant work rate treadmill tests at moderate (90?% gas exchange threshold) and heavy (?0?%) exercise intensities. Bodyweight significantly influenced the $ \dot{V}{\text{O}}_{ 2} $ kinetics during both moderate- and heavy exercise intensities (P?<?0.05). During moderate intensity exercise, the phase II τ (OB: 30?±?13 cf. NW: 22?±?7?s), mean response time (MRT; OB: 35?±?16 cf. NW: 25?±?10?s), phase II gain (OB: 156?±?21 cf. NW: 111?±?18?mLO2?kg??km?) and oxygen deficit (OB: 0.36?±?0.11 cf. NW: 0.20?±?0.06?L) were significantly higher in the OB children (all P?<?0.05). During heavy intensity exercise, the τ (OB: 33?±?9 cf. NW: 27?±?6?s; P?<?0.05) and phase II gain (OB: 212?±?61 cf. NW: 163?±?23 mLO2?kg??km?; P?<?0.05) were similarly higher in the OB children. A slow component was observed in all participants during heavy intensity exercise, but was not influenced by weight status. In conclusion, this study demonstrates that weight status significantly influences the dynamic $ \dot{V}{\text{O}}_{ 2} $ response at the onset of treadmill exercise in children and highlights that the deleterious effects of being obese are already manifest pre-puberty.