Transepithelial heme-iron transport: effect of heme oxygenase overexpression

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• 作者：M. J. Mendiburo (1)
  S. Le Blanc (1)
  A. Espinoza (1)
  F. Pizarro (1)
  M. Arredondo (1) marredon@inta.cl
• 关键词：Heme ; Fe – ; Transepithelial transport – ; Caco ; 2 cells – ; Heme oxygenase
• 刊名：European Journal of Nutrition
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：50
• 期：5
• 页码：363-371
• 全文大小：1.4 MB
• 参考文献：1. Agarwal A, Shiraishi F, Visner GA, Nick HS (1998) Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J Am Soc Nephrol 9:1990–1997
  2. Arredondo M, Orellana A, N煤帽ez MT (1997) Intracellular iron regulates iron regulatory protein activity and iron absorption in intestinal epithelial (Caco-2) cells. Am J Physiol 273(36):G275–G280
  3. Arredondo M, KIoosterman J, N煤帽ez S, Segovia F, Candia V, Flores S, Le Blanc S, Olivares M, Pizarro P (2008) Heme iron uptake by Caco-2 cells is a saturable, temperature sensitive and modulated by extracellular pH and potassium. Biol Trace Elem Res 125:109–119
  4. Beard JL, Dawson H, Pinero DJ (1996) Iron metabolism: a comprehensive review. Nutr Rev 54:295–317
  5. Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi AM (1995) Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 130:387–398
  6. Carraway MS, Ghio AJ, Taylor JL, Piantadosi CA (1998) Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. Am J Physiol Lung Cell Mol Physiol 275:L583–L592
  7. Carraway MS, Ghio AJ, Carter JD, Piantadosi CA (2000) Expression of heme oxygenase-1 in the lung in chronic hypoxia. Am J Respir Cell Mol Biol 278:L806–L812
  8. Cermak J, Baila J, Jacob HS, Baila G, Enright H, Nath K, Vercellotti GM (1993) Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensibility: possible role in chemotherapy efficacy. Cancer Res 53:5308–5313
  9. Choi AMK, Alam J (1996) Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 15:9–19
  10. Conrad ME, Umbreit JN (2000) Iron absorption and transport—an update. Am J Hematol 64:287–298
  11. Durante W, Kroll MH, Christodoulides N, Peyton KJ, Schafer AI (1997) Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ Res 80:557–564
  12. Eisenstein RS, Garcia-Mayolt D, Pettingellt W, Munro HM (1991) Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron translational control/iron-regulated proteins/metabolic regulation/iron regulatory element-binding protein/chelatable iron). Proc Nat Acad Sci USA 88:688–692
  13. Ewing JF, Maines MD (1991) Rapid induction of heme oxygenase-1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Proc Natl Acad Sci USA 88:5364–5368
  14. Eyssen-Hernandez R, Ladoux A, Frelin C (1996) Differential regulation of cardiac heme oxygenase-1 and vascular endothelial growth factor mRNA expressions by hemin, heavy metals, heat shock and anoxia. FEBS Lett 382:229–233
  15. Fogg S, Agarwal A, Nick HS, Visner GA (1999) Iron regulates hyperoxia-dependent human heme oxygenase-1 gene expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol 20:797–804
  16. Grasbeck R, Majuri R, Kouvonen I, Tenhunen R (1982) Spectral and other studies on the intestinal haem receptor of the pig. Biochem Biophys Acta 700:137–142
  17. Hayashi S, Omata Y, Sakamoto H, Higashimoto Y, Hara T, Sagara Y, Noguchi M (2004) Characterization of rat heme oxygenase-3 gene Implication of processed pseudogenes derived from heme oxygenase-2 gene. Gene 336(2):241–250
  18. Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL (2008) A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825–828
  19. Keyse SM, Tyrrell RM (1987) Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. J Biol Chem 262:14821–14825
  20. Kim HP, Wang X, Galbiati F, Ryter SW, Choi AM (2004) Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J 18:1080–1089
  21. Krishnamurthy P, Xie T, Schuetz JD (2007) The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther 114:345–358
  22. Latunde-Dada GO, Simpson RJ, McKie AT (2006) Recent advances in mammalian haem transport. Trends Biochem Sci 31:182–188
  23. Lautier D, Luscher P, Tyrrell RM (1992) Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene. Carcinogenesis 13:227–232
  24. Lee PJ, Alam J, Wiegand GW, Choi AM (1996) Overexpression of heme oxygenase-1 expression in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA 93:10393–10398
  25. Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272:5375–5381
  26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
  27. Mendiburo MJ, Flores S, Pizarro F, Arredondo M (2006) Heme oxygenase-1 overexpression increases iron fluxes in Caco-2 cells. Biol Res 39:195–197
  28. Morse D, Choi MAK (2002) Heme oxygenase-1 the “emerging molecule” has arrived. Am J Respir Cell Mol Biol 27:8–16
  29. Parmley RT, Barton JC, Conrad ME, Austin RL, Holland RM (1981) Ultraestructural cytochemistry and radioautography of hemoglobin-iron absorption. Exp Mol Pathol 34:131–134
  30. Philpott CC (2002) Molecular aspects of iron absorption: insights into the role of HFE in hemochromatosis. Hepatology 35:993–1001
  31. Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M (2003) Heme-iron absorption is saturable by heme-iron dose in women. J Nutr 133:2214–2217
  32. Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004) Identification of a human heme exporter that is essential for erythropoiesis. Cell 118:757–766
  33. Raffin SB, Woo CH, Roost KT, Price DC, Schmid R (1974) Intestinal absorption of hemoglobin heme iron cleavage by mucosal heme oxygenase. J Clin Invest 54:1344–1352
  34. Roy CN, Enns CA (2000) Iron homeostasis: new tales from the crypt. Blood 96:4020–4027
  35. Stocker R (1990) Induction of heme oxygenase as a defense against oxidative stress. Free Radic Res Commun 9:101–112
  36. Sun Y, Rotenberg MO, Maines MD (1990) Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected. J Biol Chem 265:8212–8217
  37. Takeda A, Perry G, Abraham NG, Dwyer BE, Kuttyi RK, Laitinen JT, Petersen RB, Smith MA (2000) Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau. J Biol Chem 275:5395–5399
  38. Tapia N, Arredondo M, N煤帽ez MT (1996) Regulation of Fe absorption by cultured intestinal epithelia (Caco-2) cell monolayers with varied Fe status. Am J Physiol 1271:G443–G447
  39. Trakshel GM, Kutty RK, Maines MD (1986) Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem 261:11131–11137
  40. Weintraub LR, Weinstein MB, Huser HJ, Rafal S (1968) Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa. J Clin Invest 47:531–539
  41. Wheby MS, Spyker DA (1981) Hemoglobin iron absorption kinetics in the iron-deficient dog. Am J Clin Nutr 34:1686–1693
  42. Wyllie JC, Kaufman MD (1982) An electron microscopy study of heme uptake by rat duodenum. Lab Invest 47:471–476
• 作者单位：1. Micronutrient Laboratory, Nutrition Institute and Food Technology, El L铆bano 5524, Macul, Santiago, Chile
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Background Heme iron is found in the diet mainly in the form of hemoglobin and myoglobin. It is known that heme iron (heme-Fe) and inorganic iron are absorbed differently. Intracellularly, heme oxygenase-1 (HO1) participates in the cleavage of the heme ring producing biliverdin, CO and ferrous iron. Iron released from heme becomes part of labile iron pool, and it can be stored in ferritin or released through the basolateral membrane. The mechanism by which heme-Fe is metabolized within cells is not completely understood.