Vascular endothelial growth factor -634G/C and vascular endothelial growth factor -2578C/A polymorphisms and lung cancer risk: a case–control study and meta-analysis

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• 作者：Zai-Chun Deng (1)
  Chao Cao (1)
  Yi-Ming Yu (1)
  Hong-Ying Ma (1)
  Meng Ye (2)
  
• 关键词：VEGF ; Polymorphism ; Lung cancer ; Susceptibility
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：35
• 期：3
• 页码：1805-1811
• 全文大小：252 KB
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• 作者单位：Zai-Chun Deng (1)
  Chao Cao (1)
  Yi-Ming Yu (1)
  Hong-Ying Ma (1)
  Meng Ye (2)
  
  1. Department of Respiratory Medicine, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, Zhejiang, China
  2. Department of Medical Oncology, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, Zhejiang, China
  
• ISSN：1423-0380

文摘

Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis. In present study, we conducted a case–control study and meta-analysis to evaluate the genetic effects of VEGF -634G/C and VEGF -2578C/A polymorphisms and risk of lung cancer. A total of 175 subjects were recruited for case–control study and seven studies were included in the meta-analysis. Our case–control study showed that VEGF -634G/C polymorphism had no association with lung cancer risk (CC vs. GG: OR--.88, 95?% CI--.37-.11), whereas there was an association between VEGF -2578CC genotype and decrease in lung cancer risk (CC vs. CA/AA: OR--.52, 95?% CI--.28-.96). A meta-analysis was further performed and statistically similar results were obtained (CC vs. GG: OR--.91, 95?% CI--.60-.39 for VEGF ?34; CC vs. AA: OR--.53, 95?% CI--.32-.89 for VEGF ?578). Our study showed that the variant genotypes of the VEGF -2578C/A polymorphism, but not the VEGF -634G/C polymorphism, was associated with lung cancer risk. More studies are needed to detect VEGF -634G/C and VEGF ?578 polymorphisms and their association with lung cancer in different ethnic populations incorporated with environmental exposures.