Facile preparation of a pH-sensitive nano-magnetic targeted system to deliver doxorubicin to tumor tissues

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• 作者：Juan Wu ; Shanshan Xu ; Wei Jiang ; Yueqing Shen ; Menglu Pu
• 关键词：Doxorubicin ; Iron oxide ; Nano ; magnetic targeted particles ; pH ; sensitivity ; Tumor therapeutics
• 刊名：Biotechnology Letters
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：37
• 期：3
• 页码：585-591
• 全文大小：1,683 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776

文摘

We have developed a drug-loaded, pH-sensitive, nano-magnetic targeted system (DPNTS) for delivering doxorubicin (DOX) to tumor tissues through a facile route. Iron oxide (Fe3O4) nanoparticles were used as magnetically-responsive carriers, polyethyleneglycol (PEG) as the surface-modifying agent, and polyethyleneimine (PEI) as the drug-loading site whose primary amine reacts with the 13-carbonyl of DOX. The prepared DPNTS was within 20?nm and had good stability in dispersion and superparamagnetic properties. DOX was grafted to PEG/PEI@Fe3O4 at up to 85?%. During in vitro release studies, nearly 81?% DOX was released from DPNTS within 72?h at pH 4.5, compared with only 28?% at pH 7.4.