TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells
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- 作者：Xiao Wu ; Meng-Yao Wu ; Min Jiang ; Qiaoming Zhi ; Xiaojie Bian…
- 关键词：TNF ; α ; Chemotherapy sensitization ; Radiotherapy sensitization ; Breast cancer
- 刊名：Cancer Cell International
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：5483KB
- 刊物主题：Cancer Research; Cell Biology;
- 出版者：BioMed Central
- ISSN：1475-2867
- 卷排序：17
文摘
PurposeDespite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment. Therefore, finding ways to reduce the toxicity and increase sensitivity is particularly important. Tumor necrosis factor alpha (TNF-α) exerts multiple functions in cell proliferation, differentiation and apoptosis. In the present study, we investigated whether TNF-α could enhance the effect of chemotherapy and radiotherapy against breast cancer cells.