文摘
Gallbladder carcinoma (GBC) is the most common cancer of the biliary tract. Lymph node metastasis (LNM) is the major diffusion route of GBC and is a prognosis factor. The aim of study was to assess the potential of the serum VEGF-C and VEGF-D (sVEGF-C/D) levels to predict the presence of LNM and the survival of GBC patients. The preoperative sVEGF-C/D levels of 31 patients with GBC, 10 patients with cholesterol polyps, and 10 healthy volunteers were measured by enzyme-linked immunoadsorbent assay (ELISA). The sVEGF-C/D levels of patients with GBC were significantly higher than those of people with healthy gallbladders (p-lt;-.001 and p--.001, respectively) and cholesterol polyp (p--.032 and p--.004, respectively). In GBC, the sVEGF-C levels were associated with LNM (p--.011), distant metastasis (p--.018), and stage (p--.045), but the sVEGF-D levels had a significant association with the tumor depth (p--.001), LNM (p--.001), distant metastasis (p--.047), and stage (p--.002). The sVEGF-C/D diagnostic values for the presence of GBC were sensitivity of 71.0 and 74.2 % and specificity of 80.0 and 85.0 %, respectively. With respect to the diagnosis of LNM, the diagnostic values of sVEGF-C/D were as follows: sensitivity 81.2 and 87.5 % and specificity 73.3 and 80.0 %, respectively. The mean survival time with high sVEGF-C was significantly shorter than that with low sVEGF-C (p-lt;-.001), which was also true for low sVEGF-D (p--.032). The preoperative sVEGF-C/D levels might be reliable biomarkers for the presence of disease and LNM in patients with GBC. The sVEGF-C/D levels may be prognosis factors that can predict a poor outcome for GBC patients. Keywords Gallbladder carcinoma Serum VEGF-C Serum VEGF-D Lymph nodes metastases Prognosis