文摘
Background MicroRNAs (miRNAs, miRs) are involved in most physiological, developmental, and pathological processes. miR-192 and miR-205 are expressed preferentially in the renal cortex and closely relevant to the renal cell biology. In the present study, we aim to measure the serum levels of miR-192 and miR-205 and their correlation with clinicopathological data in patients with primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Methods Fifty-six patients (35 male, 21 female) with idiopathic nephrotic syndrome (FSGS 30, MCD 26) and 20 healthy controls were enrolled in the study. We quantified the serum levels of miR-192 and miR-205 in patients with FSGS and MCD by RT-qPCR. Results Patients with FSGS had higher serum levels of miR-192 and miR-205 than those with MCD (324.49?±-2.74 fmol/l versus 90.19?±-7.14 fmol/l, p-lt;-.01, 2.25?±-.69 fmol/l versus 0.60?±-.51 fmol/l, p-lt;-.01, respectively). The level of miR-192 was positively correlated with the proteinuria in patients with FSGS and MCD (r--.62, p-lt;-.001, r--.84, p-lt;-.001, respectively). Similarly, the level of miR-205 was positively correlated with the proteinuria in patients with FSGS (r--.54, p--.002). In addition, the serum level of miR-192 was significantly correlated with the degree of interstitial fibrosis in patients with FSGS (r--.342, p-lt;-.05). Conclusions miR-192 and miR-205 have the potential as markers to differentiate FSGS from MCD.