A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis

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• 作者：Meripet Polat ; Shin-nosuke Takeshima ; Kazuyoshi Hosomichi ; Jiyun Kim…
• 关键词：Bovine leukemia virus (BLV) ; Next generation sequencing ; BLV whole genome analysis ; gp51 env sequencing ; Phylogenetic analysis ; South America
• 刊名：Retrovirology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：5,343 KB
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• 作者单位：Meripet Polat (1) (2)
  Shin-nosuke Takeshima (1) (2)
  Kazuyoshi Hosomichi (3)
  Jiyun Kim (1)
  Taku Miyasaka (1)
  Kazunori Yamada (1)
  Mariluz Arainga (1)
  Tomoyuki Murakami (1)
  Yuki Matsumoto (1)
  Veronica de la Barra Diaz (4)
  Carlos Javier Panei (5) (7)
  Ester Teresa González (5)
  Misao Kanemaki (6)
  Misao Onuma (1)
  Guillermo Giovambattista (7)
  Yoko Aida (1) (2)
  
  1. Viral Infectious Diseases Unit, RIKEN, 2–1 Hirosawa, Wako, Saitama, 351-0198, Japan
  2. Laboratory of Viral Infectious Diseases, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, Wako, Saitama, 351-0198, Japan
  3. Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Takara-machi 13-1, Kanazawa, Ishikawa, 920-8640, Japan
  4. LAVET, Carampangue 595, Valdivia, Chile
  5. Department of Virology, Faculty of Veterinary Sciences, National University of La Plata, 60 and 118, CC 296, 1900, La Plata, Argentina
  7. IGEVET, CCT La Plata-CONICET, Facultad de Ciencias Veterinarias, National University of La Plata, 60 and 118, CC 296, 1900, La Plata, Argentina
  6. Institute for Animal Science, Shitara-cho, Aichi, 441-2433, Japan
  
• 刊物主题：Virology; Infectious Diseases; Cancer Research;
• 出版者：BioMed Central
• ISSN：1742-4690

文摘

Background Bovine leukemia virus (BLV) is a member of retroviridae family, together with human T cell leukemia virus types 1 and 2 (HTLV-1 and -2) belonging to the genes deltaretrovirus, and infects cattle worldwide. Previous studies have classified the env sequences of BLV provirus from different geographic locations into eight genetic groups. To investigate the genetic variability of BLV in South America, we performed phylogenetic analyses of whole genome and partial env gp51 sequences of BLV strains isolated from Peru, Paraguay and Bolivia, for which no the molecular characteristics of BLV have previously been published, and discovered a novel BLV genotype, genotype-9, in Bolivia.