miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway

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• 作者：Shuzhi Zhao ; Tao Li ; Jun Li ; Qianyi Lu ; Changjing Han ; Na Wang ; Qinghua Qiu…
• 关键词：Diabetic retinopathy ; Metabolic memory ; miR ; 23b ; 3p ; NF ; κB ; SIRT1
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：59
• 期：3
• 页码：644-654
• 全文大小：2,327 KB
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• 作者单位：Shuzhi Zhao (1)
  Tao Li (1)
  Jun Li (2)
  Qianyi Lu (1)
  Changjing Han (1)
  Na Wang (1)
  Qinghua Qiu (1)
  Hui Cao (1)
  Xun Xu (1)
  Haibing Chen (3)
  Zhi Zheng (1)
  
  1. Department of Ophthalmology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University, Haining Road 100, Shanghai, 200080, People’s Republic of China
  2. Department of Ophthalmology, Lishui City Center Hospital, Lishui, People’s Republic of China
  3. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Yishan Road 301, Shanghai, 200233, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis The mechanisms underlying the cellular metabolic memory induced by high glucose remain unclear. Here, we sought to determine the effects of microRNAs (miRNAs) on metabolic memory in diabetic retinopathy.