Low Magnesium Levels in Adults with Metabolic Syndrome: a Meta-Analysis
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- 作者：Sang A. La ; June Young Lee ; Do Hoon Kim ; E Lang Song…
- 关键词：Magnesium ; Trace elements ; Serum ; Hair ; Mononuclear leukocytes ; Metabolic syndrome X ; Insulin resistance ; Observational study ; Meta ; analysis
- 刊名：Biological Trace Element Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：170
- 期：1
- 页码：33-42
- 全文大小：891 KB
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June Young Lee (2)
Do Hoon Kim (3)
E Lang Song (1)
Jin Hee Park (4)
Sang Yhun Ju (1)
1. Department of Family Medicine, College of Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 150-713, Republic of Korea
2. Department of Biostatistics, College of Medicine, Korea University, 145, Anam-ro, Seongbuk-gul, 136-701, Republic of Korea
3. Department of Family Medicine, Korea University Ansan Hospital, 516, Gojan 1-Dong, Danwon-Gu, Ansan-Si Gyeonggi-Do, 425-707, Republic of Korea
4. Department of Research, Research and Development Center, Food and Drug Networking Co., Ltd, Seoul, Republic of Korea - 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
- 出版者：Springer US
- ISSN：1559-0720
文摘
There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based on 13 eligible studies involving 14 analyses and 5496 enrolled participants, magnesium levels were significantly lower in adults with metabolic syndrome than in controls (standardized mean difference [SMD] = −0.98, 95 % confidence interval [CI] = −1.44 to −0.52). There was marked heterogeneity when all comparisons were considered (I 2 = 98 %, p < 0.001). In the subgroup meta-analysis and meta-regression model, a significant difference in magnesium levels was noted by geographic location and study quality. Magnesium levels were lower in the experimental cases than in the controls in West Asia (SMD = −3.80, 95 % CI = −5.36, −2.23) and Latin America (SMD = −1.38, 95 % CI = −1.88, −0.87), but not in East Asia (SMD = −0.01, 95 % CI = −0.30, 0.29) or Europe/Oceania (SMD = −0.25, 95 % CI = −0.53, 0.03). Moreover, the inverse association was greater in high-quality studies (SMD = −2.52, 95 % CI = −3.72, −1.32) than in low-quality studies (SMD = −0.33, 95 % CI = −0.57, −0.08). In conclusion, although there was a high level of heterogeneity, this meta-analysis provided convincing evidence of reduced magnesium levels in adults with metabolic syndrome based on the findings of observational studies. However, the present findings should be validated by additional prospective studies or trans-regional multicenter randomized controlled trials, which generally yield higher-level evidence than case–control studies and cross-sectional studies. Clinical Trial Registration Number: NCT02151227 (ClinicalTrials.gov Protocol Registration System); CRD42015017946 (www.crd.york.ac.uk/PROSPERO). Keywords Magnesium Trace elements Serum Hair Mononuclear leukocytes Metabolic syndrome X Insulin resistance Observational study Meta-analysis