Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver

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• 作者：Joana F. Sacramento ; Maria J. Ribeiro ; Tiago Rodrigues ; Elena Olea…
• 关键词：Adipose tissue ; Carotid sinus nerve ; Glucose homeostasis ; Insulin sensitivity ; Liver
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：1
• 页码：158-168
• 全文大小：862KB
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisWe recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver.