Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain
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- 作者：Anne M. Maliszewski-Hall ; Michelle Alexander ; Ivan Tkáč ; Gülin Öz…
- 关键词：IUGR ; Brain ; Metabolism ; Magnetic resonance spectroscopy
- 刊名：Neurochemical Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：42
- 期：1
- 页码：133-140
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Neurochemistry; Biochemistry, general; Cell Biology; Neurology;
- 出版者：Springer US
- ISSN：1573-6903
- 卷排序：42
文摘
Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.