Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism
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- 作者：Valery Veprinskiy ; Leonhard Heizinger ; Maximilian G. Plach…
- 关键词：Primary metabolism ; Secondary metabolism ; Enzyme evolution ; Enzyme design
- 刊名：BMC Evolutionary Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：917KB
- 刊物主题：Evolutionary Biology; Animal Systematics/Taxonomy/ Biogeography; Entomology; Genetics and Population Dynamics; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2148
- 卷排序：17
文摘
BackgroundMicrobes, plants, and fungi synthesize an enormous number of metabolites exhibiting rich chemical diversity. For a high-level classification, metabolism is subdivided into primary (PM) and secondary (SM) metabolism. SM products are often not essential for survival of the organism and it is generally assumed that SM enzymes stem from PM homologs.