Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis

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作者：Nabil Bosco (1)
Viral Brahmbhatt (1)
Manuel Oliveira (1)
Francois-Pierre Martin (1) (4)
Pia Lichti (2)
Frederic Raymond (1) (4)
Robert Mansourian (1)
Sylviane Metairon (1) (4)
Cecil Pace-Asciak (3)
Viktoria Bastic Schmid (1)
Serge Rezzi (1) (4)
Dirk Haller (2)
Jalil Benyacoub (1)
关键词：Inflammation ; Inflammatory bowel disease ; Eicosanoids ; Eicosapentaenoic acid ; Docosahexaenoic acid ; Omega ; 3 fatty acids
刊名：Lipids in Health and Disease
出版年：2013
出版时间：December 2013
年：2013
卷：12
期：1
全文大小：591KB
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作者单位：Nabil Bosco (1)
Viral Brahmbhatt (1)
Manuel Oliveira (1)
Francois-Pierre Martin (1) (4)
Pia Lichti (2)
Frederic Raymond (1) (4)
Robert Mansourian (1)
Sylviane Metairon (1) (4)
Cecil Pace-Asciak (3)
Viktoria Bastic Schmid (1)
Serge Rezzi (1) (4)
Dirk Haller (2)
Jalil Benyacoub (1)

1. Nestlé Research Center, Vers-chez-les-Blanc, Lausanne 26, CH-1000, Switzerland
4. Nestlé Institute of Health Sciences SA, EPFL campus, Quartier de l’innovation, Building G, Lausanne, 1015, Switzerland
2. ZIEL–Research Center for Nutrition and Food Science, CDD - Center for Diet and Disease, Technische Universit?t München, Biofunctionality, Gregor-Mendel-Stra?e 2, Freising-Weihenstephan, 85350, Germany
3. Research Institute, The Hospital for Sick Children, E. McMaster Building, Toronto, Canada

文摘

Background Inflammatory bowel diseases (IBD) are chronic intestinal inflammatory diseases affecting about 1% of western populations. New eating behaviors might contribute to the global emergence of IBD. Although the immunoregulatory effects of omega-3 fatty acids have been well characterized in vitro, their role in IBD is controversial. Methods The aim of this study was to assess the impact of increased fish oil intake on colonic gene expression, eicosanoid metabolism and development of colitis in a mouse model of IBD. Rag-2 deficient mice were fed fish oil (FO) enriched in omega-3 fatty acids i.e. EPA and DHA or control diet for 4 weeks before colitis induction by adoptive transfer of na?ve T cells and maintained in the same diet for 4 additional weeks. Onset of colitis was monitored by colonoscopy and further confirmed by immunological examinations. Whole genome expression profiling was made and eicosanoids were measured by HPLC-MS/MS in colonic samples. Results A significant reduction of colonic proinflammatory eicosanoids in FO fed mice compared to control was observed. However, neither alteration of colonic gene expression signature nor reduction in IBD scores was observed under FO diet. Conclusion Thus, increased intake of dietary FO did not prevent experimental colitis.

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