Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells
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- 作者：Emma M. Corr ; Clare C. Cunningham ; Laura Helbert…
- 关键词：BCP crystals ; Inflammation ; Syk ; PI3K ; S100 proteins
- 刊名：Arthritis Research & Therapy
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：19
- 期：1
- 全文大小：1425KB
- 刊物主题：Rheumatology; Orthopedics;
- 出版者：BioMed Central
- ISSN：1478-6362
- 卷排序：19
文摘
BackgroundOsteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA joints and are associated with severe degeneration. They are known to activate macrophages, synovial fibroblasts, and articular chondrocytes, resulting in increased cell proliferation and the production of pro-inflammatory cytokines and matrix metalloproteases (MMPs). This suggests a pathogenic role in OA by causing extracellular matrix degradation and subchondral bone remodelling. There are currently no disease-modifying drugs available for crystal-associated OA; hence, the aim of this study was to explore the inflammatory pathways activated by BCP crystals in order to identify potential therapeutic targets to limit crystal-induced inflammation.