ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

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• 作者：Sighild Lemarchant ; Yuriy Pomeshchik ; Iurii Kidin…
• 关键词：A desintegrin and metalloproteinase with thrombospondin motifs ; Amyotrophic lateral sclerosis ; Extracellular matrix ; Neurodegeneration ; Perineuronal net ; Chondroitin sulfate proteoglycan ; Astrogliosis ; Nerve growth factor ; Brain ; derived neurotrophic factor ; Glial cell ; derived neurotrophic factor
• 刊名：Molecular Neurodegeneration
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：11
• 期：1
• 全文大小：2,568 KB
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• 作者单位：Sighild Lemarchant (1)
  Yuriy Pomeshchik (1)
  Iurii Kidin (1)
  Virve Kärkkäinen (1)
  Piia Valonen (1)
  Sarka Lehtonen (1)
  Gundars Goldsteins (1)
  Tarja Malm (1)
  Katja Kanninen (1)
  Jari Koistinaho (1)
  
  1. Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland
  
• 刊物主题：Neurosciences; Neurology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1750-1326

文摘

Background A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuroplasticity. Despite the beneficial effect of ADAMTS-4 on neurorepair after spinal cord injury, the functions of ADAMTS proteoglycanases in other CNS disease states have not been studied. Therefore, we investigated the expression, effects and associated mechanisms of ADAMTS-4 during amyotrophic lateral sclerosis (ALS) in the SOD1G93A mouse model.