Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis

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• 作者：Heya Na ; Xiaoli Liu ; Xiaomeng Li ; Xinsheng Zhang…
• 关键词：DC ; SIGNR ; Colon cancer liver metastasis ; Metallothioneins
• 刊名：Journal of Hematology & Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：4788KB
• 刊物主题：Oncology; Hematology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-8722
• 卷排序：10

文摘

BackgroundTumor metastasis is an essential cause of the poor prognosis of colon cancer. DC-SIGNR is a C-type lectin that is frequently found on human liver sinusoidal endothelial cells. LSECtin, which is a homologue of DC-SIGNR, has been demonstrated to participate in colon cancer liver metastasis. Due to the similarities in the expression pattern and structure of the two proteins, we speculated that DC-SIGNR could also be involved in this process.