Peripheral primitive neuroectodermal tumor/primary cutaneous Ewing’s sarcoma (PPNET/ES) of the upper eyelid in an adult patient

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• 作者：Corrado Rubino ; Pietro Mulas ; Antonio Contu…
• 关键词：PPNET ; Peripheral primitive neuroectodermal tumor ; Ewing’s sarcoma ; Eyelid ; Adult
• 刊名：European Journal of Plastic Surgery
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：37
• 期：10
• 页码：559-562
• 全文大小：596 KB
• 参考文献：1. Banerjee SS, Agbamu DA, Eyden BP, Harris M (1997) Clinicopathological characteristics of peripheral primitive neuroectodermal tumour of skin and subcutaneous tissue. Histopathology 31(4):355-6
  2. Angervall L, Enzinger FM (1975) Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer 36(1):240-1 CrossRef
  3. Chow E, Merchant TE, Pappo A, Jenkins JJ, Shah AB, Kun LE (2000) Cutaneous and subcutaneous Ewing’s sarcoma: an indolent disease. Int J Radiat Oncol Biol Phys 46(2):433- CrossRef
  4. Chung CH, Wang CH, Wang TY, Huang JK, Leu YS (2006) Extraskeletal Ewing sarcoma mimicking a thyroid nodule. Thyroid 16(10):1065- CrossRef
  5. Cotterill SJ, Ahrens S, Paulussen M, Jürgens HF, Vo?te PA, Gadner H, Craft AW (2000) Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol 18(17):3108-4
  6. Craft A, Cotterill S, Malcolm A, Spooner D, Grimer R, Souhami R, Imeson J, Lewis I (1998) Ifosfamide-containing chemotherapy in Ewing’s sarcoma: the Second United Kingdom Children’s Cancer Study Group and the Medical Research Council Ewing’s Tumor Study. J Clin Oncol 16(11):3628-3
  7. Dunst J, Jürgens H, Sauer R, Pape H, Paulussen M, Winkelmann W, Rübe C (1995) Radiation therapy in Ewing’s sarcoma: an update of the CESS 86 trial. Int J Radiat Oncol Biol Phys 32(4):919-0 CrossRef
  8. Ehrig T, Billings SD, Fanburg-Smith JC (2007) Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity? Ann Diagn Pathol 11(3):153- CrossRef
  9. Fizazi K, Dohollou N, Blay JY, Guérin S, Le Cesne A, André F, Pouillart P, Tursz T, Nguyen BB (1998) Ewing’s family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. J Clin Oncol 16(12):3736-3
  10. Gostout BS, Lindor NM, DiMarco CS, Peethambaram PP, Clayton AC (2003) Pelvic primitive neuroectodermal tumor associated with a cluster of small round cell tumors: case report and review of current literature. Gynecol Oncol 91(1):247-3 CrossRef
  11. Hasegawa SL, Davison JM, Rutten A, Fletcher JA, Fletcher CD (1998) Primary cutaneous Ewing’s sarcoma: immunophenotypic and molecular cytogenetic evaluation of five cases. Am J Surg Pathol 22(3):310- CrossRef
  12. Jenkin RD (1995) Ewing’s sarcoma: radiation treatment at the primary site-regarding Dunst et al., IJROBP 32:919-30; 1995. Int J Radiat Oncol Biol Phys 32(4):1253- CrossRef
  13. Kumar S, Pack S, Kumar D, Walker R, Quezado M, Zhuang Z, Meltzer P, Tsokos M (1999) Detection of EWS-FLI-1 fusion in Ewing’s sarcoma/peripheral primitive neuroectodermal tumor by fluorescence in situ hybridization using formalin-fixed paraffin-embedded tissue. Hum Pathol 30(3):324-0 CrossRef
  14. Lee CS, Southey MC, Slater H, Auldist AW, Chow CW, Venter DJ (1995) Primary cutaneous Ewing’s sarcoma/peripheral primitive neuroectodermal tumors in childhood. A molecular, cytogenetic, and immunohistochemical study. Diagn Mol Pathol 4(3):174-1 CrossRef
  15. Meyer WH, Kun L, Marina N, Roberson P, Parham D, Rao B, Fletcher B, Pratt CB (1992) Ifosfamide plus etoposide in newly diagnosed Ewing’s sarcoma of bone. J Clin Oncol 10(11):1737-2
  16. Parham DM (2001) Neuroectodermal and neuroendocrine tumors principally seen in children. Am J Clin Pathol 115(Suppl):S113-8
  17. Sexton CW, White WL (1996) Primary cutaneous Ewing’s family sarcoma. Report of a case with immunostaining for glycoprotein p30/32 mic2. Am J Dermatopathol 18(6):601- CrossRef
  18. Verrill MW, Judson IR, Harmer CL, Fisher C, Thomas JM, Wiltshaw E (1997) Ewing’s sarcoma and primitive neuroectodermal tumor in adults: are they different from Ewing’s sarcoma and primitive neuroectodermal tumor in children? J Clin Oncol 15(7):2611-1
  
• 作者单位：Corrado Rubino (1)
  Pietro Mulas (2)
  Antonio Contu (3)
  Francesco Farace (2)
  Francesco Tanda (4)
  Michele Angelo Bella (4)
  Antonio Pazzola (3)
  
  1. Department of Medicine and Surgery, Plastic Surgery Unit, University of Salerno, Salerno, Italy
  2. Plastic Surgery Unit, University Hospital Trust, University of Sassari, Sassari, Italy
  3. Department of Oncology, SS. Annunziata Hospital, Sassari, Italy
  4. Department of Pathology, University Hospital Trust, University of Sassari, Sassari, Italy
  
• ISSN：1435-0130

文摘

Peripheral primitive neuroectodermal tumor (PPNET) and Ewing’s sarcoma (ES) are two variants of a highly malignant bone tumor usually affecting children and young adults with a tendency for early metastasis. Cutaneous localization of PPNET/ES is very uncommon in adult age and is normally confused with other tumors. We report the first recorded case of PPNET of the eyelid in an adult patient. The patient underwent one biopsy, two surgical wide excisions, and two series of 4?cycles of chemotherapy without radiotherapy. At 8?years of follow-up from the first wide excision, the patient is tumor free. Cutaneous PPNET/ES is rare and not considered in the usual differential diagnosis of skin lesions, especially those involving the eyelid. Once diagnosed, a multidisciplinary approach to treatment offers the highest survival rates. Level of Evidence: Level V, diagnostic study.