Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction
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- 作者：Rongchuan Yue ; Wenbin Fu ; Xiang Liao ; Cong Lan ; Qiao Liao…
- 关键词：Metformin ; Cardiosphere ; derived cells ; Myocardial infarction ; AMP ; activated protein kinase
- 刊名：Stem Cell Research & Therapy
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：8
- 期：1
- 全文大小：3100KB
- 刊物主题：Stem Cells; Cell Biology;
- 出版者：BioMed Central
- ISSN：1757-6512
- 卷排序：8
文摘
BackgroundTransplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficial effect. Metformin (MET) activates AMP-activated protein kinase (AMPK) which is associated with cell survival. The aim of this study is to determine whether MET improves CDC survival in the transplantation microenvironment and enhances the therapeutic effect of CDC transplantation against MI.