Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia

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• 作者：T. Bauters (1)
  V. Mondelaers (2)
  H. Robays (1)
  H. De Wilde (3)
  Y. Benoit (2)
  B. De Moerloose (2)
  
• 关键词：Clinical pharmacy ; Hemolytic anemia ; Methemoglobinemia ; Pancreatitis ; Pediatric hemato ; oncology ; Rasburicase
• 刊名：International Journal of Clinical Pharmacy
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：35
• 期：3
• 页码：303-305
• 全文大小：197KB
• 参考文献：1. Ueng S. Rasburicase (Elitek): a novel agent for tumor lysis syndrome. Proc (Bayl Univ Med Cent). 2005;18(3):275-.
  2. Pui CH, Mahmoud HH, Wiley JM, Woods GM, Leverger G, Camitta B, et al. Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma. J Clin Oncol. 2001;19(3):697-04.
  3. Cairo MS. Prevention and treatment of hyperuricemia in hematological malignancies. Clin Lymphoma. 2002; Suppl 1:S26-1.
  4. de Bont JM, Pieters R. Management of hyperuricemia with rasburicase review. Nucleosides Nucleotides Nucleic Acids. 2004;23(8-):1431-0. CrossRef
  5. Browning LA, Kruse J. Hemolysis and methemoglobinemia secondary to rasburicase administration. Ann Pharmacother. 2005;39(11):1932-. CrossRef
  6. Maher JF, Rath CE, Schreiner GE. Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis. Arch Intern Med. 1969;123(2):198-00. CrossRef
  7. E-Compendium. Scientific Leaflet Fasturtec (in Flemish). Available from: http://www.ecompendium.be/. Accessed on 12 May 2010.
  8. Goldman SC, Holcenberg JS, Finklestein JZ, Hutchinson R, Kreissman S, Johnson FL, et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97(10):2998-003. CrossRef
  9. Kizer N, Martinez E, Powell M. Report of two cases of rasburicase-induced methemoglobinemia. Leuk Lymphoma. 2006;47(12):2648-0. CrossRef
  10. Identifying Adverse Drug Reactions. Available from http://qmweb.dads.state.tx.us/MedSim/Naranjo.htm. Accessed on 14 Apr 2010.
  11. Borinstein SC, Xu M, Hawkins DS. Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. Pediatr Blood Cancer. 2008;50(1):189. CrossRef
  12. Bhat P, Sisler I, Collier AB 3rd. Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient. Pediatr Blood Cancer. 2008;51(4):568. CrossRef
  13. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356(9237):1255-. CrossRef
  
• 作者单位：T. Bauters (1)
  V. Mondelaers (2)
  H. Robays (1)
  H. De Wilde (3)
  Y. Benoit (2)
  B. De Moerloose (2)
  
  1. Department of Pharmacy, Ghent University Hospital, -1 K12, De Pintelaan 185, 9000, Ghent, Belgium
  2. Department of Pediatric Hemato-Oncology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
  3. Department of Pediatric Cardiology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
  
• ISSN：2210-7711

文摘

Case We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3?days of supportive therapy. Conclusion Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.