Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate
详细信息 查看全文
- 作者：Sayaka Kato ; Katsuaki Ito ; Yukio Kato ; Tomohiko Wakayama ; Yoshiyuki Kubo ; Shoichi Iseki and Akira Tsuji
- 关键词：KEY WORDS intestinal crypt compartment cells ; methotrexate ; MRP1 ; toxicity ; transporters
- 刊名：Pharmaceutical Research
- 出版年：2009
- 出版时间：June, 2009
- 年：2009
- 卷：26
- 期：6
- 页码：1467-1476
- 全文大小：399.4 KB
文摘
Purpose Methotrexate (MTX) causes dose-limiting gastrointestinal toxicity due to exposure of intestinal tissues, and is a substrate of the multidrug resistance-associated protein (MRP) 1. Here we examine the involvement of MRP1, which is reported to be highly expressed in the proliferative crypt compartment of the small intestine, in the gastrointestinal toxicity of MTX.