The Effect of Molecular Weight, Drug Load, and Charge of Gelatin¨CMTX Conjugates on Growth Inhibition of HL-60 Leukemia Cells

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• 作者：Chao-Sheng Chen and Clyde M. Ofner
• 关键词：KEY WORDS charge ; drug load ; HL ; 60 growth inhibition ; macromolecular drug conjugates ; molecular weight
• 刊名：Pharmaceutical Research
• 出版年：2009
• 出版时间：February, 2009
• 年：2009
• 卷：26
• 期：2
• 页码：338-345
• 全文大小：199.6 KB

文摘

Purpose Gelatin–methotrexate conjugates (G-MTX) with known molecular weight (MW), drug load, and charge were prepared and evaluated for growth inhibition on leukemia cells.