Development of poly(vinyl acetate-methylacrylic acid)/chitosan/Fe3O4 nanoparticles for the diagnosis of non-alcoholic steatohepatitis with magnetic resonance imaging
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- 作者：Xiadan Luo (1)
Xiaoli Song (1)
Aiping Zhu (1)
Yunfeng Si (1)
Lijun Ji (1)
Zhanrong Ma (2)
Zhiyun Jiao (2)
Jingtao Wu (3) - 刊名：Journal of Materials Science Materials in Medicine
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：23
- 期：12
- 页码：3075-3082
- 全文大小：712KB
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Xiaoli Song (1)
Aiping Zhu (1)
Yunfeng Si (1)
Lijun Ji (1)
Zhanrong Ma (2)
Zhiyun Jiao (2)
Jingtao Wu (3)
1. College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, People’s Republic of China
2. Department of Radiology, The People’s First Hospital of Yangzhou City, Yangzhou, 225001, People’s Republic of China
3. Department of Radiology, Clinical Medical College of Yangzhou University, Yangzhou, 225001, People’s Republic of China - ISSN：1573-4838
文摘
Non-alcoholic steatohepatitis is a burgeoning health problem. To diagnose NASH with magnetic resonance imaging (MRI), an effective contrast agent, a stable suspension of superparamagnetic Fe3O4 nanoparticles, were newly developed. The negatively charged Fe3O4 nanoparticles were coated with positive chitosan (CS) firstly, and then assembled with poly(vinyl acetate-methylacrylic acid) (P(VAc-MAA)). Transmission electron microscope and dynamic light scattering confirmed that the obtained P(VAc-MAA)/CS/Fe3O4 nanoparticles had a spherical or ellipsoidal morphology with an average diameter in the range of 14-0?nm. The superparamagnetic property and spinel structure of the Fe3O4 nanoparticles were well preserved due to the protection of the P(VAc-MAA)/CS layers on the surface of the Fe3O4 nanoparticles. The in vivo rat experiments confirmed that the P(VAc-MAA)/CS/Fe3O4 nanoparticles were an effective contrast agent for MRI to diagnose NASH.