Morphologie und Progression der prim?ren Varikose

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• 作者：Dr. C. Wilmanns ; S. Katsandris ; A. Cooper ; L. Wockner ; N. Glaser…
• 关键词：Prim?re Varikose ; Morphologie ; Komplikationen ; Methylentetrahydrofolatreduktase ; Polymorphismen ; Primary varicose veins ; Morphology ; Complications ; Methylenetetrahydrofolate reductase ; Polymorphisms
• 刊名：Gef?sschirurgie
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：20
• 期：5
• 页码：370-375
• 全文大小：655 KB
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  4.Chiesa R, Marone EM, Limoni C, Volonté M, Schaefer E, Petrini O (2005) Chronic venous insufficiency in Italy: the 24-cities cohort study. Eur J Vasc Endovasc Surg 30:422-29View Article
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  9.Evans CJ, Fowkes FGR, Ruckley CV, Lee AJ (1999) Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health 53:149-53PubMed Central View Article
  10.Fernández-Peralta AM, Daimiel L, Nejda N, Iglesias D, Arana VM, González-Aguilera JJ (2010) Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy. Int J Colorectal Dis 25:141-51View Article
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• 作者单位：Dr. C. Wilmanns (1)
  S. Katsandris (2)
  A. Cooper (3)
  L. Wockner (4)
  N. Glaser (3)
  O. Bartsch (3)
  H. Binder (4)
  A. Meyer (2)
  G. Hoffmann (1)
  P.K. Walter (5)
  U. Zechner (3)
  
  1. Klinik für Gef??chirurgie, St?dtisches Klinikum, Gotenstra?e 1, 42653, Solingen, Deutschland
  2. Klinik für Allgemeine, Viszeral- und Gef??chirurgie, Johanniter-Krankenhaus, 47228, Duisburg, Deutschland
  3. Institut für Humangenetik, Universit?tsmedizin, Johannes-Gutenberg-Universit?t, 55131, Mainz, Deutschland
  4. Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universit?tsmedizin, Johannes-Gutenberg-Universit?t, 55131, Mainz, Deutschland
  5. Sektion Gef??chirurgie und Endovascul?re Chirurgie, Maria-Hilf-Krankenhaus, 54550, Daun, Deutschland
  
• 刊物主题：Vascular Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1434-3932

文摘

Background Primary varicose vein disease should be treated by stage-adjusted therapy in order to prevent possible complications. The pathogenesis of primary varicose vein disease is still unknown. Objectives An obvious heritability stresses the need for a genetic distinction between potential sources of axial reflux as well as of complicated disease. Results Examination of blood and tissue specimens from 116 patients with primary varicose veins as well as from 36 controls yielded a significant association of two common polymorphisms of the MTHFR gene with two principal morphological phenotypes, c.677C>T with trunk type and junctional incompetence (p-lt;-.01) and c.1298A>C with perforator type with and without axial reflux (p-lt;-.01). A significant association of the c.1298A>C mutation with progression towards complicated disease grades C3- according to the CEAP classification was detected (p-lt;-.01). Recent results from 52 extremities of 34 patients suggest a significantly greater diameter of perforator veins observed in cases of CEAP C3- compared with C2 (p--.02). Conclusions The results support a classification of primary varicose veins according to functional reflux, a selective elimination of relevant insufficiency factors and raise the question of prophylactic genetic testing.