Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase
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- 作者：Danielle R Ellis (1) (2)
Thomas G Sors (1)
Dennis G Brunk (1)
Carrie Albrecht (1)
Cindy Orser (3)
Brett Lahner (1)
Karl V Wood (4)
Hugh H Harris (5) (6)
Ingrid J Pickering (5) (7)
David E Salt (1) - 刊名：BMC Plant Biology
- 出版年：2004
- 出版时间：December 2004
- 年：2004
- 卷：4
- 期：1
- 全文大小：1039KB
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Thomas G Sors (1)
Dennis G Brunk (1)
Carrie Albrecht (1)
Cindy Orser (3)
Brett Lahner (1)
Karl V Wood (4)
Hugh H Harris (5) (6)
Ingrid J Pickering (5) (7)
David E Salt (1)
1. Center for Plant Environmental Stress Physiology, 1165 Horticulture Building, Purdue University, West Lafayette, IN, 47907, USA
2. Visiting Scientist: NuCycle Therapy, Inc, Hillside, NJ, 07205, USA
3. Arete Associates, Gaithersburg, MD, 20878, USA
4. Chemistry Department, Purdue University, West Lafayette, IN, 47907, USA
5. Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, Menlo Park, CA, 94025, USA
6. School of Chemistry, University of Sydney, NSW, 2006, Australia
7. Department of Geological Science, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada
文摘
Background It has become increasingly evident that dietary Se plays a significant role in reducing the incidence of lung, colorectal and prostate cancer in humans. Different forms of Se vary in their chemopreventative efficacy, with Se-methylselenocysteine being one of the most potent. Interestingly, the Se accumulating plant Astragalus bisulcatus (Two-grooved poison vetch) contains up to 0.6% of its shoot dry weight as Se-methylselenocysteine. The ability of this Se accumulator to biosynthesize Se-methylselenocysteine provides a critical metabolic shunt that prevents selenocysteine and selenomethionine from entering the protein biosynthetic machinery. Such a metabolic shunt has been proposed to be vital for Se tolerance in A. bisulcatus. Utilization of this mechanism in other plants may provide a possible avenue for the genetic engineering of Se tolerance in plants ideally suited for the phytoremediation of Se contaminated land. Here, we describe the overexpression of a selenocysteine methyltransferase from A. bisulcatus to engineer Se-methylselenocysteine metabolism in the Se non-accumulator Arabidopsis thaliana (Thale cress). Results By over producing the A. bisulcatus enzyme selenocysteine methyltransferase in A. thaliana, we have introduced a novel biosynthetic ability that allows the non-accumulator to accumulate Se-methylselenocysteine and γ-glutamylmethylselenocysteine in shoots. The biosynthesis of Se-methylselenocysteine in A. thaliana also confers significantly increased selenite tolerance and foliar Se accumulation. Conclusion These results demonstrate the feasibility of developing transgenic plant-based production of Se-methylselenocysteine, as well as bioengineering selenite resistance in plants. Selenite resistance is the first step in engineering plants that are resistant to selenate, the predominant form of Se in the environment.