Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice
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- 作者：Jacqueline M. Barker ; Daniel H. Lench ; L. Judson Chandler
- 关键词：Alcohol ; Metabotropic glutamate receptors ; Cue ; mediated behavior
- 刊名：Psychopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：233
- 期：2
- 页码：235-242
- 全文大小：706 KB
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Daniel H. Lench (1)
L. Judson Chandler (1)
1. Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology
Psychiatry - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-2072
文摘
Rationale Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alcohol exposure leads to these impairments will enable further investigation of the neurobiological mechanisms by which it acts to dysregulate adaptive behavior.