Mechano-biological Coupling of Cellular Responses to Microgravity

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• 作者：Mian Long ; Yuren Wang ; Huiqiong Zheng ; Peng Shang…
• 关键词：Microgravity ; Mechanobiology ; Mechanotransduction ; Cells
• 刊名：Microgravity Science and Technology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：27
• 期：6
• 页码：505-514
• 全文大小：669 KB
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• 作者单位：Mian Long (1) (2)
  Yuren Wang (1)
  Huiqiong Zheng (3)
  Peng Shang (4)
  Enkui Duan (5)
  Dongyuan L眉 (1) (2)
  
  1. Key Laboratory of Microgravity (National Microgravity Laboratory), Institute of Mechanics, Chinese Academy of Sciences (CAS), No. 15 North 4th Ring Road, Beijing, 100190, China
  2. Center for Biomechanics and Bioengineering and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences (CAS), No. 15 North 4th Ring Road, Beijing, 100190, China
  3. Laboratory of Photosynthesis and Environmental Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China
  4. School of Life Sciences, Northwestern Polytechnical University, Xi鈥檃n, Xi鈥檃n, China
  5. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS, Beijing, China
  
• 刊物类别：Engineering
• 刊物主题：Extraterrestrial Physics and Space Sciences
  Aerospace Technology and Astronautics
  Classical Continuum Physics
  
• 出版者：Springer Netherlands
• ISSN：1875-0494

文摘

Cellular response to microgravity is a basic issue in space biological sciences as well as space physiology and medicine. It is crucial to elucidate the mechano-biological coupling mechanisms of various biological organisms, since, from the principle of adaptability, all species evolved on the earth must possess the structure and function that adapts their living environment. As a basic element of an organism, a cell usually undergoes mechanical and chemical remodeling to sense, transmit, transduce, and respond to the alteration of gravitational signals. In the past decades, new computational platforms and experimental methods/techniques/devices are developed to mimic the biological effects of microgravity environment from the viewpoint of biomechanical approaches. Mechanobiology of plant gravisensing in the responses of statolith movements along the gravity vector and the relevant signal transduction and molecular regulatory mechanisms are investigated at gene, transcription, and protein levels. Mechanotransduction of bone or immune cell responses and stem cell development and tissue histogenesis are elucidated under microgravity. In this review, several important issues are briefly discussed. Future issues on gravisensing and mechanotransducing mechanisms are also proposed for ground-based studies as well as space missions. Keywords Microgravity Mechanobiology Mechanotransduction Cells