Gene expression profiling reveals distinct features of various porcine adipose tissues

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• 作者：Chaowei Zhou (13)
  Jie Zhang (13)
  Jideng Ma (13)
  Anan Jiang (13)
  Guoqing Tang (13)
  Miaomiao Mai (13)
  Li Zhu (13)
  Lin Bai (13)
  Mingzhou Li (13)
  Xuewei Li (13)
  
• 关键词：Gene expression profiling ; Subcutaneous adipose tissues ; Visceral adipose tissues ; Pig
• 刊名：Lipids in Health and Disease
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：12
• 期：1
• 全文大小：2098KB
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• 作者单位：Chaowei Zhou (13)
  Jie Zhang (13)
  Jideng Ma (13)
  Anan Jiang (13)
  Guoqing Tang (13)
  Miaomiao Mai (13)
  Li Zhu (13)
  Lin Bai (13)
  Mingzhou Li (13)
  Xuewei Li (13)
  
  13. Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya鈥檃n, Sichuan, 625000, China
  

文摘

Background The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level. Results We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response. Conclusions The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity.