The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-2 Years): a double-blind randomized study

详细信息    查看全文

• 作者：Jeffrey R Stout (1)
  B Sue Graves (2)
  Abbie E Smith (1)
  Michael J Hartman (2)
  Joel T Cramer (1)
  Travis W Beck (1)
  Roger C Harris (3)
  
• 刊名：Journal of the International Society of Sports Nutrition
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：5
• 期：1
• 全文大小：368KB
• 参考文献：1. Harris RC, Marlin DJ, Dunnett M, Snow DH, Hultman E: Muscle buffering capacity and dipeptide content in the thoroughbred horse, greyhound dog and man. / Comp Biochem Physiol A 1990,97(2):249-51. CrossRef
  2. Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA: The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. / Amino acids 2006,30(3):279-89. CrossRef
  3. Stuerenburg HJ, Kunze K: Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles. / Archives of gerontology and geriatrics 1999,29(2):107-13. CrossRef
  4. Tallon MJ, Harris RC, Maffulli N, Tarnopolsky MA: Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects. / Biogerontology 2007,8(2):129-37. CrossRef
  5. Brooks SV, Faulkner JA: Skeletal muscle weakness in old age: underlying mechanisms. / Medicine and science in sports and exercise 1994,26(4):432-39.
  6. Chandler JM, Hadley EC: Exercise to improve physiologic and functional performance in old age. / Clinics in geriatric medicine 1996,12(4):761-84.
  7. Doherty TJ, Vandervoort AA, Taylor AW, Brown WF: Effects of motor unit losses on strength in older men and women. / J Appl Physiol 1993,74(2):868-74. CrossRef
  8. Alexander NB, Schultz AB, Ashton-Miller JA, Gross MM, Giordani B: Muscle strength and rising from a chair in older adults. / Muscle & nerve 1997, 5:S56-9. CrossRef
  9. Kannus P, Parkkari J, Niemi S, Palvanen M: Fall-induced deaths among elderly people. / American journal of public health 2005,95(3):422-24. CrossRef
  10. deVries HA, Brodowicz GR, Robertson LD, Svoboda MD, Schendel JS, Tichy AM, Tichy MW: Estimating physical working capacity and training changes in the elderly at the fatigue threshold (PWCft). / Ergonomics 1989,32(8):967-77. CrossRef
  11. Moritani T, Takaishi T, Matsumoto T: Determination of maximal power output at neuromuscular fatigue threshold. / J Appl Physiol 1993,74(4):1729-734.
  12. Stout J, Eckerson J, Ebersole K, Moore G, Perry S, Housh T, Bull A, Cramer J, Batheja A: Effect of creatine loading on neuromuscular fatigue threshold. / J Appl Physiol 2000,88(1):109-12.
  13. deVries HA, Tichy MW, Housh TJ, Smyth KD, Tichy AM, Housh DJ: A method for estimating physical working capacity at the fatigue threshold (PWCFT). / Ergonomics 1987,30(8):1195-204. CrossRef
  14. Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, Smith AE, Walter AA: Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64 -86 years). / The journal of nutrition, health & aging 2007,11(6):459-64.
  15. Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA: Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. / Amino acids 2007,32(2):225-33. CrossRef
  16. Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok DJ, Zoeller RF: Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. / Journal of strength and conditioning research/National Strength & Conditioning Association 2006,20(4):928-31.
  17. Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy J: Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. / Amino acids 2007,32(3):381-86. CrossRef
  18. Beltran B, Cuadrado C, Martin ML, Carbajal A, Moreiras O: Activities of daily living in the Spanish elderly. Association with mortality. / The journal of nutrition, health & aging 2001,5(4):259-60.
  19. deVries HA, Housh TJ: Physical Fitness Testing (ch. 14). / Physiology of Exercise / 5 Edition Dubuque, IA: Wm.C. Brown Publishers 1994, 254-82.
  20. Kim HJ: Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmers. / Amino acids 2008.
  21. Fitts RH, Holloszy JO: Lactate and contractile force in frog muscle during development of fatigue and recovery. / The American journal of physiology 1976,231(2):430-33.
  22. Marsh GD, Paterson DH, Thompson RT, Cheung PK, MacDermid J, Arnold JM: Metabolic adaptations to endurance training in older individuals. / Canadian journal of applied physiology = Revue canadienne de physiologie appliquee 1993,18(4):366-78.
  23. Harris RC, Jones G, Hill CH, Kendrick IP, Boobis L, Kim CK, Kim HJ, Dang VH, Edge J, Wise JA: The carnosine content of vastus lateralis in vegetarians and omnivores. / FASEB J 2007, 21:76.20. CrossRef
  
• 作者单位：Jeffrey R Stout (1)
  B Sue Graves (2)
  Abbie E Smith (1)
  Michael J Hartman (2)
  Joel T Cramer (1)
  Travis W Beck (1)
  Roger C Harris (3)
  
  1. Department of Health and Exercise Science, University of Oklahoma, Norman, OK, USA
  2. Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL, USA
  3. School of Sport Exercise and Health Sciences, University of Chichester, Chichester, West Sussex, UK
  

文摘

Background Ageing is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing beta-alanine has been shown to significantly increase skeletal muscle carnosine. The purpose of this study, therefore, was to examine the effects of ninety days of beta-alanine supplementation on the physical working capacity at the fatigue threshold (PWCFT) in elderly men and women. Methods Using a double-blind placebo controlled design, twenty-six men (n = 9) and women (n = 17) (age ± SD = 72.8 ± 11.1 yrs) were randomly assigned to either beta-alanine (BA: 800 mg × 3 per day; n = 12; CarnoSyn? or Placebo (PL; n = 14) group. Before (pre) and after (post) the supplementation period, participants performed a discontinuous cycle ergometry test to determine the PWCFT. Results Significant increases in PWCFT (28.6%) from pre- to post-supplementation were found for the BA treatment group (p < 0.05), but no change was observed with PL treatment. These findings suggest that ninety days of BA supplementation may increase physical working capacity by delaying the onset of neuromuscular fatigue in elderly men and women. Conclusion We suggest that BA supplementation, by improving intracellular pH control, improves muscle endurance in the elderly. This, we believe, could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.