A guide to human in vivo microcirculatory flow image analysis

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• 作者：Michael J. Massey ; Nathan I. Shapiro
• 刊名：Critical Care
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：20
• 期：1
• 全文大小：634 KB
• 参考文献：1.Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med. 1999;5:1209–12.CrossRef PubMed
  2.Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, et al. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med. 2009;35:1761–6.CrossRef PubMed
  3.Bezemer R, Bartels SA, Bakker J, Ince C. Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill—where do we stand. Crit Care. 2012;16:224–33.PubMedCentral CrossRef PubMed
  4.Bezemer R, Dobbe JG, Bartels SA, Boerma EC, Elbers PW, Heger M, et al. Rapid automatic assessment of microvascular density in sidestream dark field images. Med Biol Eng Comput. 2011;49:1269–78.PubMedCentral CrossRef PubMed
  5.Boerma EC, Mathura KR, van der Voort PH, Spronk PE, Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care. 2005;9:R601–6.PubMedCentral CrossRef PubMed
  6.Bracht H, Krejci V, Hiltebrand L, Brandt S, Sigurdsson G, Ali SZ, et al. Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion. Intensive Care Med. 2008;34:1883–90.CrossRef PubMed
  7.De Backer D, Hollenberg S, Boerma C, Goedhart P, Buchele G, Ospina-Tascon G, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11:R101.PubMedCentral CrossRef PubMed
  8.De Backer D, Ospina-Tascon G, Salgado D, Favory R, Creteur J, Vincent JL. Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med. 2010;36:1813–25.CrossRef PubMed
  9.De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med. 2006;34:1918–24.CrossRef PubMed
  10.den Uil CA, Caliskan K, Lagrand WK, van der Ent M, Jewbali LS, van Kuijk JP, et al. Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure. Intensive Care Med. 2009;35:1893–9.CrossRef
  11.den Uil CA, Lagrand WK, Spronk PE, van der Ent M, Jewbali LS, Brugts JJ, et al. Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure. Eur J Heart Fail. 2009;11:386–90.CrossRef
  12.Dobbe JG, Streekstra GJ, Atasever B, van Zijderveld R, Ince C. Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis. Med Biol Eng Comput. 2008;46:659–70.PubMedCentral CrossRef PubMed
  13.Donati A, Damiani E, Domizi R, Romano R, Adrario E, Pelaia P, et al. Alteration of the sublingual microvascular glycocalyx in critically ill patients. Microvasc Res. 2013;90:86–9.CrossRef PubMed
  14.Donati A, Domizi R, Damiani E, Adrario E, Pelaia P, Ince C. From macrohemodynamic to the microcirculation. Crit Care Res Pract. 2013;2013:892710.PubMedCentral PubMed
  15.Kanoore Edul VS, Enrico C, Laviolle B, Vazquez AR, Ince C, Dubin A. Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med. 2012;40:1443–8.CrossRef
  16.Elbers PW, Ince C. Mechanisms of critical illness—classifying microcirculatory flow abnormalities in distributive shock. Crit Care. 2006;10:221.PubMedCentral CrossRef PubMed
  17.Ellis CG, Jagger J, Sharpe M. The microcirculation as a functional system. Crit Care. 2005;9 Suppl 4:S3–8.PubMedCentral CrossRef PubMed
  18.Eriksson S, Nilsson J, Sturesson C. Non-invasive imaging of microcirculation: a technology review. Med Devices (Auckl). 2014;7:445–52.
  19.Ince C. The elusive microcirculation. Intensive Care Med. 2008;34:1755–6.CrossRef PubMed
  20.Ince C. The microcirculation is the motor of sepsis. Crit Care. 2005;9 Suppl 4:S13–9.PubMedCentral CrossRef PubMed
  21.Massey MJ, Larochelle E, Najarro G, Karmacharla A, Arnold R, Trzeciak S, et al. The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care. 2013;28:913–7.CrossRef PubMed
  22.Milstein DMJ, Lindeboom JAH, Ince C. Sidestream dark-field imaging and image analysis of oral microcirculation under clinical conditions. Anaesth Pain Intensive Care Emerg. Proceedings of the 20th Postgraduate Course in Critical Care Medicine Trieste, Italy—November 18–21, 2005. 2006;Chapter 6:79–88.
  23.Omar YG, Massey M, Andersen LW, Giberson TA, Berg K, Cocchi MN, et al. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation. 2013;84:1717–22.CrossRef PubMed
  24.Robertson R, Lockhart E, Shapiro NI, Bankarenko N, McMahon T, Massey MJ, et al. Impact of transfusion of autologous 7 versus 42 day old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion. 2012;52:2459–64.CrossRef
  25.Sakr Y, Chierego M, Piagnerelli M, Verdant C, Dubois MJ, Koch M, et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med. 2007;35:1639–44.CrossRef PubMed
  26.Sallisalmi M. Microcirculation and hemorheology in critically ill patients. PhD thesis, Dept. of Surgery Division of Anesthesia and Intensive Care Medicine. University of Helsinki, Helsinki, Finland. 2013. ISBN 978-952-10-8687-8 (PDF).
  27.Sallisalmi M, Oksala N, Pettila V, Tenhunen J. Evaluation of sublingual microcirculatory blood flow in the critically ill. Acta Anaesthesiol Scand. 2012;56:298–306.CrossRef PubMed
  28.Sheikh MY, Javed U, Singh J, Choudhury J, Deen O, Dhah K, et al. Bedside sublingual video imaging of microcirculation in assessing bacterial infection in cirrhosis. Dig Dis Sci. 2009;54:2706–11.PubMedCentral CrossRef PubMed
  29.Struijker-Boudier HA, Rosei AE, Bruneval P, Camici PG, Christ F, Henrion D, et al. Evaluation of the microcirculation in hypertension and cardiovascular disease. Eur Heart J. 2007;28:2834–40.CrossRef PubMed
  30.Taccone FS, Su F, Pierrakos C, He X, James S, Dewitte O, et al. Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care. 2010;14:R140.PubMedCentral CrossRef PubMed
  31.Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med. 2007;49:88–98. 98e1–2.CrossRef PubMed
  32.Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008;34:2210–7.PubMedCentral CrossRef PubMed
  33.Trzeciak S, Rivers EP. Clinical manifestations of disordered microcirculatory perfusion in severe sepsis. Crit Care. 2005;9 Suppl 4:S20–6.PubMedCentral CrossRef PubMed
  34.van Beers EJ, Goedhart PT, Unger M, Biemond BJ, Ince C. Normal sublingual microcirculation during painful crisis in sickle cell disease. Microvasc Res. 2008;76:57–60.CrossRef PubMed
  35.van Elteren HA, Ince C, Tibboel D, Reiss IK, de Jonge RC. Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging. J Clin Monit Comput. 2015;29:543–8.PubMedCentral CrossRef PubMed
  36.Verdant CL, De Backer D, Bruhn A, Clausi CM, Su F, Wang Z, et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med. 2009;37:2875–81.CrossRef PubMed
  37.Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care. 2005;9 Suppl 4:S9–12.PubMedCentral CrossRef PubMed
  38.Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, et al. International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med. 2015;43:48–56.CrossRef PubMed
  39.Dababneh L, Cikach F, Alkukhun L, Dweik RA, Tonelli AR. Sublingual microcirculation in pulmonary arterial hypertension. Ann Am Thorac Soc. 2014;11:504–12.PubMedCentral CrossRef PubMed
  40.Aykut G, Veenstra G, Scorcella C, Ince C, Boerma C. Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation. Intensive Care Med Exp. 2015;3:40.CrossRef PubMed
  41.Bezemer R, Khalilzada M, Ince C. Recent advancements in microcirculatory image acquisition and analysis. In: Yearbook of intensive care and emergency medicine. Berlin: Springer; 2008. p. 677–90.CrossRef
  42.De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98–104.CrossRef PubMed
  43.Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med. 2004;32:1825–31.CrossRef PubMed
  44.Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet. 2002;360:1395–6.CrossRef PubMed
  45.Sherman H, Klausner S, Cook WA. Incident dark-field illumination a new method for microcirculation study. Angiology. 1971;22:295–303.CrossRef PubMed
  46.Goedhart PT, Khalilzada M, Bezemer R, Merza J, Ince C. Sidestream dark field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express. 2007;15:15101–14.CrossRef PubMed
  47.Balestra GM, Bezemer R, Boerma EC, Yong ZY, Sjauw KD, Engstrom AE, et al. Improvement of sidestream dark field imaging with an image acquisition stabilizer. BMC Med Imaging. 2010;10:15.PubMedCentral CrossRef PubMed
  48.Lindert J, Werner J, Redlin M, Kuppe H, Habazettl H, Pries AR. OPS imaging of human microcirculation. A short technical report. J Vasc Res. 2002;39:368–72.CrossRef PubMed
  49.Demir SU, Mirshahi N, Tiba MH, Draucker G, Ward KR, Hobson R, et al. Image processing and machine learning for diagnostic analysis of microcirculation. ICME International Conference Complex Medical Engineering, 9–11 April 2009. 2009:1–5. http://​ieeexplore.​ieee.​org/​xpl/​abstractSimilar.​jsp?​tp=​&​arnumber=​4906669&​url=​http%3A%2F%2Fieeexplore.​ieee.​org%2Fxpls%2Fabs_​all.​jsp%3Farnumber%3D4906669 .
  50.Demir SU, Hakimzadeh R, Hargraves RH, Ward KR, Myer EV, Najarian K. An automated method for analysis of microcirculation videos for accurate assessment of tissue perfusion. BMC Med Imaging. 2012;12:37–50.PubMedCentral CrossRef PubMed
  51.Demir SU, Mirshahi N. Ward K, Hakimzadeh R. Hobson R, Najarian K. Vessel extraction of microcirculatory video recordings using multi-thresholding based verification algorithm. 2010 International Conference on Biosciences (BIOSCIENCESWORLD); 7–13 March 2010:11–15. doi:10.​1109/​BioSciencesWorld​.​2010.​9
  52.You S, Ataer-Cansizoglu E, Erdogmus D, Massey M, Shapiro N. Microvascular blood flow estimation in sublingual microcirculation videos based on a principal curve tracing algorithm. 2012 IEEE Int Workshop Machine Learning for Signal Proc (MLSP); 23–26 Sept. 2012:1–6. doi:10.​1109/​MLSP.​2012.​6349763
  53.You S, Massey M, Shapiro N, Erdogmus D. A novel line detection method in space-time images for microvascular blood flow analysis in sublingual microcirculatory videos. 2013 IEEE 10th Int Symposium on Biomed Imaging; 7–11 April 2013:828–31. doi:10.​1109/​ISBI.​2013.​6556603 .
  54.Pozo MO, Kanoore Edul VS, Ince C, Dubin A. Comparison of different methods for the calculation of the microvascular flow index. Crit Care Res Pract. 2012;2012:102483.PubMedCentral PubMed
  
• 作者单位：Michael J. Massey (1)
  Nathan I. Shapiro (1) (2)
  
  1. Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
  2. The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, 99 Brookline Ave., Boston, MA, 02215, USA
  
• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Various noninvasive microscopic camera technologies have been used to visualize the sublingual microcirculation in patients. We describe a comprehensive approach to bedside in vivo sublingual microcirculation video image capture and analysis techniques in the human clinical setting. We present a user perspective and guide suitable for clinical researchers and developers interested in the capture and analysis of sublingual microcirculatory flow videos. We review basic differences in the cameras, optics, light sources, operation, and digital image capture. We describe common techniques for image acquisition and discuss aspects of video data management, including data transfer, metadata, and database design and utilization to facilitate the image analysis pipeline. We outline image analysis techniques and reporting including video preprocessing and image quality evaluation. Finally, we propose a framework for future directions in the field of microcirculatory flow videomicroscopy acquisition and analysis. Although automated scoring systems have not been sufficiently robust for widespread clinical or research use to date, we discuss promising innovations that are driving new development. Electronic supplementary materialThe online version of this article (doi:10.​1186/​s13054-016-1213-9) contains supplementary material, which is available to authorized users.