A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer
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- 作者：Chantel Samardzija ; Rodney B Luwor ; Mila Volchek ; Michael A Quinn…
- 关键词：Ovarian carcinoma ; Cancer stem cells ; Metastasis ; Ascites ; Chemoresistance ; Recurrence ; Oct4A
- 刊名：Molecular Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：14
- 期：1
- 全文大小：3,164 KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
文摘
Background High grade epithelial ovarian cancer (EOC) is commonly characterised by widespread peritoneal dissemination and ascites. Metastatic EOC tumour cells can attach directly to neighbouring organs or alternatively, maintain long term tumourigenicity and chemoresistance by forming cellular aggregates (spheroids). Cancer stem-like cells are proposed to facilitate this mechanism. This study aimed to investigate the role of Oct4A, an embryonic stem cell factor and known master regulator of pluripotency in EOC progression, metastasis and chemoresistance.