CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation

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• 作者：Michael A. Rogers ; Verena Kalter…
• 关键词：Gene expression ; Colorectal cancer ; Microarray ; Tight junctions ; Adherens junctions ; c ; MET ; Actin ; Claudins ; Ezrin ; CITED4
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：142
• 期：1
• 页码：225-237
• 全文大小：1,701 KB
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• 作者单位：Michael A. Rogers (1)
  Verena Kalter (1)
  Gemma Marcias (1)
  Marc Zapatka (1)
  Sebastian Barbus (1)
  Peter Lichter (1)
  
  1. Division of Molecular Genetics (B060), German Cancer Research Center, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Purpose CITED4 is one member of a family of transcriptional cofactors, several of which are deregulated in a variety of tumors, including colorectal cancer (CRC). We modulated CITED4 expression, in vitro, and analyzed the associated phenotypic and gene expression changes.