Wasserzeichen in synthetischen Genen

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• 作者：Michael Liss ; Ralf Wagner
• 刊名：BIOspektrum
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：22
• 期：2
• 页码：151-153
• 全文大小：601 KB
• 参考文献：[1]Clelland C, Risca V, Bancroft C (1999) Hiding messages in DNA microdots. Nature 399:533–534CrossRef PubMed
  [2]Gibson DG, Glass JI, Lartigue C et al. (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329:52–56CrossRef PubMed
  [3]Heider D, Barnekow A (2008) DNA watermarks: a proof of concept. BMC Mol Biol 9:e40CrossRef
  [4]Raab D, Graf M, Notka F et al. (2010) The GeneOptimizer Algorithm: using a sliding window approach to cope with the vast sequence space in multiparameter DNA sequence optimization. Syst Synth Biol 4:215–225CrossRef PubMed PubMedCentral
  [5]Fath S, Bauer AP, Liss M et al. (2011) Multiparameter RNA and codon optimization: a standardized tool to assess and enhance autologous mammalian gene expression. PLoS One 6:e17596CrossRef PubMed PubMedCentral
  [6]Maertens B, Spriestersbach A, von Groll U et al. (2010) Gene optimization mechanisms: a multi-gene study reveals a high success rate of full-length human proteins expressed in Escherichia coli. Protein Sci 19:1312–1326CrossRef PubMed PubMedCentral
  [7]Liss M, Daubert D, Brunner K et al. (2012) Embedding permanent watermarks in synthetic genes. PLoS One 7:e42465CrossRef PubMed PubMedCentral
  [8]Shimanovsky B, Feng J, Potkonjak M (2003) Hiding Data in DNA. In: Petitcolas FAP (Hrsg) Information Hiding. 5th International Workshop, IH 2002 Noordwijkerhout, The Netherlands. Springer, Berlin, 373–386CrossRef
  
• 作者单位：Michael Liss (1)
  Ralf Wagner (2)
  
  1. Thermo Fisher Scientific GENEART GmbH, Am Biopark 11, D-93053, Regensburg, Deutschland
  2. Institut für Mikrobiologie und Hygiene, Universität Regensburg, Regensburg, Deutschland
  
• 刊物主题：Life Sciences, general; Biochemistry, general; Human Genetics; Microbiology; Developmental Biology; Pharmacology/Toxicology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-6249

文摘

Like other high-value products labelling of genes or organisms will become important not only to pinpoint their identity, origin, or spread, but also for intellectual property, classification, bio-security or legal reasons. An adaptation of steganographic techniques used in digital media protection offers a versatile method to inseparably interlace digital watermarks into coding genes.