LDOC-1 and PARP-1 mRNA expression in leukocytes of father and son with cutaneous malignant melanoma

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• 作者：Michele Salemi (1)
  Pier Franco Soma (2)
  Rosita A. Condorelli (1)
  Domenico Recupero (1)
  Aldo E. Calogero (1)
  
• 关键词：Cutaneous malignant melanoma ; Apoptosis ; LDOC ; 1gene ; PARP ; 1 gene ; qRT ; PCR
• 刊名：Central European Journal of Medicine
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：8
• 期：2
• 页码：204-207
• 全文大小：311KB
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• 作者单位：Michele Salemi (1)
  Pier Franco Soma (2)
  Rosita A. Condorelli (1)
  Domenico Recupero (1)
  Aldo E. Calogero (1)
  
  1. Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, via S. Sofia 78, 95123, Catania, Italy
  2. Plastic Surgery and Burns Centre, Cannizzaro Hospital, Catania, Italy
  

文摘

Apoptosis is central to the biology of cutaneous malignant melanoma (CMM). The leucine zipper, down regulated in cancer 1 (LDOC-1) gene, is known to be a regulator of the nuclear factor kappa B (NF-kB) through inhibition of the same NF-kB. The poly (ADP-ribose) polymerase-1 (PARP1) gene plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required for the apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. We report here two interesting cases of family melanoma, a father and son 84 and 40 years old, respectively. The histological evaluation of the lesions of both men revealed diffused superficial melanoma with epithelioid cells. We evaluated the differential expression of LDOC-1 and PARP-1 mRNA in peripheral blood leukocytes of both the father and son. We found that both LDOC-1 and PARP-1 genes were down-regulated in both patients compared with those of controls. These data suggest that low levels of expression of LDOC-1 and PARP-1 mRNA may be associated with familial melanoma.