High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice

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• 作者：Yuzaburo Uetake (1) (2)
  Hitoshi Ikeda (3) (4)
  Rie Irie (5)
  Kazuaki Tejima (6)
  Hiromitsu Matsui (1)
  Sayoko Ogura (1) (7)
  Hong Wang (1)
  ShengYu Mu (8)
  Daigoro Hirohama (1)
  Katsuyuki Ando (1)
  Tatsuya Sawamura (10) (9)
  Yutaka Yatomi (3)
  Toshiro Fujita (1) (8)
  Tatsuo Shimosawa (1) (3)
  
  1. Department of Nephrology and Endocrinology ; The University of Tokyo Graduate School of Medicine ; Tokyo ; Japan
  2. Office for Research Ethics Support ; The University of Tokyo Graduate School of Medicine ; Tokyo ; Japan
  3. Clinical Laboratory ; The University of Tokyo Hospital ; Tokyo ; Japan
  4. Department of Gastroenterology ; The University of Tokyo Graduate School of Medicine ; Tokyo ; Japan
  5. Department of Pathology ; Kawasaki Municipal Hospital ; Kawasaki ; Japan
  6. Department of Gastroenterology ; Toshiba General Hospital ; Tokyo ; Japan
  7. Division of Laboratory Medicine ; Department of Pathology and Microbiology ; Faculty of Medicine ; Nihon University School of Medicine ; Tokyo ; Japan
  8. Division of Clinical Epigenetics ; Research Center for Advanced Science and Technology ; The University of Tokyo ; Tokyo ; Japan
  10. Department of Physiology ; Shinshu University School of Medicine ; Nagano ; Japan
  9. Department of Vascular Physiology ; National Cerebral and Cardiovascular Center Research Institute ; Osaka ; Japan
  
• 关键词：High salt diet induced oxidative stress ; Oxidative stress ; NADPH oxidase ; Anti ; oxidant tempol ; Nonalcoholic fatty liver disease
• 刊名：Lipids in Health and Disease
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：14
• 期：1
• 全文大小：1,418 KB
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• 刊物主题：Lipidology; Medical Biochemistry;
• 出版者：BioMed Central
• ISSN：1476-511X

文摘

Background It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome. Methods We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice. Results High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice. Conclusions We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH.