Complement evasion by Bordetella pertussis: implications for improving current vaccines

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• 作者：Ilse Jongerius (1) (2)
  Tim J. Schuijt (1) (3)
  Frits R. Mooi (1)
  Elena Pinelli (1)
  
  1. Centre for Infectious Disease Control ; National Institute for Public Health and the Environment ; Antonie van Leeuwenhoeklaan 9 ; P.O. Box 1 ; 3720 BA ; Bilthoven ; The Netherlands
  2. Department of Medical Microbiology ; University Medical Center Utrecht ; Heidelberglaan 100 ; 3584 CX ; Utrecht ; The Netherlands
  3. Department of Clinical Chemistry ; Hematology and Immunology ; Diakonessenhuis ; Bosboomstraat 1 ; 3582 KE ; Utrecht ; The Netherlands
  
• 关键词：Complement ; Bordetella pertussis ; Innate immunity ; Evasion ; Vaccine
• 刊名：Journal of Molecular Medicine
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：93
• 期：4
• 页码：395-402
• 全文大小：1,854 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Molecular Medicine
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1440

文摘

Bordetella pertussis causes whooping cough or pertussis, a highly contagious disease of the respiratory tract. Despite high vaccination coverage, reported cases of pertussis are rising worldwide and it has become clear that the current vaccines must be improved. In addition to the well-known protective role of antibodies and T cells during B. pertussis infection, innate immune responses such as the complement system play an essential role in B. pertussis killing. In order to evade this complement activation and colonize the human host, B. pertussis expresses several molecules that inhibit complement activation. Interestingly, one of the known complement evasion proteins, autotransporter Vag8, is highly expressed in the recently emerged B. pertussis isolates. Here, we describe the current knowledge on how B. pertussis evades complement-mediated killing. In addition, we compare this to complement evasion strategies used by other bacterial species. Finally, we discuss the consequences of complement evasion by B. pertussis on adaptive immunity and how identification of the bacterial molecules and the mechanisms involved in complement evasion might help improve pertussis vaccines.